Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species

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dc.contributor.authorGarcés, María
dc.contributor.authorSanchez, Elizabeth
dc.contributor.authorTorres Sierra, Alejandra L.
dc.contributor.authorRuíz Parra, Ariel
dc.contributor.authorAngel Müller, Edith
dc.contributor.authorGomez, Martín
dc.contributor.authorRomero Infante, Ximena Carolina
dc.contributor.authorCastañeda, Zoila
dc.contributor.authorSanchez Rebordelo, Estrella
dc.contributor.authorDiéguez, Carlos
dc.contributor.authorNogueiras, Rubén
dc.contributor.authorCaminos, Jorge
dc.contributor.orcidRomero Infante, Ximena Carolina [0000-0002-7040-2705]
dc.contributor.orcidRomero Infante, Ximena Carolina [0000-0002-7040-2705]
dc.date.accessioned2020-07-06T20:47:33Z
dc.date.available2020-07-06T20:47:33Z
dc.date.issued2014
dc.description.abstractenglishObjective: Pregnancy is characterized by several metabolic changes that promote fat gain and later onset of insulin resistance. As Brain-derived neurotrophic factor (BDNF) decreases hyperglycaemia and hyperphagia, we aimed to investigate the potential role of placental and circulating BDNF levels in these pregnancy-related metabolic changes in rats and humans. Design and methods: We identified the mRNA and protein expression of placental BDNF and its receptor TrkB using real-time PCR, Western blot and immunohistochemical approaches in both rat and humans. Serum BDNF was measured by ELISA. We also did a longitudinal prospective cohort study in 42 pregnant women to assess BDNF levels and correlations with other metabolic parameters. Results: We found that BDNF and TrkB are expressed in both rat and human placenta. In rat, both placental mRNA and serum levels are increased throughout pregnancy, whereas their protein levels are significantly decreased at the end of gestation. Serum BDNF levels in pregnant women are significantly lower in the first trimester when compared to the second and third trimester (P < 0·0148, P < 0·0012, respectively). Serum BDNF levels were negatively correlated with gestational age at birth and fasting glucose levels. Conclusion: Our findings suggest that both BDNF and its receptor TrkB are expressed in rodent and human placenta being regulated during pregnancy. Taken together, these findings support a role of BDNF in the regulation of several metabolic functions during pregnancy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/cen.12391
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1365-2265
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3330
dc.language.isoeng
dc.publisherJohn Wiley and Sonsspa
dc.publisher.journalClinical Endocrinologyspa
dc.relation.ispartofseriesClinical Endocrinology, 1365-2265, Vol. 81, 2014, p. 141–151spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/cen.12391
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2013-12-15
dc.rights.localAcceso abiertospa
dc.subject.decsFactor neurotrófico derivadospa
dc.subject.decsHumanosspa
dc.subject.decsMarcadores séricosspa
dc.titleBrain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both speciesspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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