Morphological and biochemical characterisation of sensory neurons infected in vitro with rabies virus

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dc.contributor.authorMartinez-Gutierrez, Marlen
dc.contributor.authorCastellanos, Jaime
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.date.accessioned2020-01-22T21:07:18Z
dc.date.available2020-01-22T21:07:18Z
dc.date.issued2007
dc.description.abstractenglishThis work was aimed at the morphological and biochemical characterisation of the most susceptible neuronal subpopulation to rabies virus (RABV) infection. Adult mouse DRG cultures were infected with RABV and double-processed for viral antigen detection and neuropeptides: calcitonine gene-related peptide (CGRP), galanin (GAL), substance P (SP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP). It was found that 56% of the neurons in culture were small (diameter <20 m) but, in spite of this, 69% of the infected neurons had intermediate and large diameters (̧20 m). More than 50% of infected neurons expressed NPY, VIP or SP, whereas no association was found between infected neurons and the presence of CGRP or GAL. Despite SP having been shown to be a small neuron marker, it was found that RABV infects medium and large-sized SP positive cells. RABV preference for larger neurons could explain part of the neuropathogenesis since it can be suggested that, following a rabid accident, the virus uses large neurons (mainly innervating muscle and joints) in vivo to be transported later on to the central nervous system.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00401-007-0222-9
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0001-6322
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1903
dc.language.isoeng
dc.publisherSpringer Verlagspa
dc.publisher.journalActa neuropathologicaspa
dc.relation.ispartofseriesActa neuropathologica, 0001-6322, Nro.114, 2007, p. 263-269spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00401-007-0222-9
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf210
dc.rights.creativecommons2007
dc.rights.localAcceso cerradospa
dc.subject.decsAntígenos viralesspa
dc.subject.decsPéptido intestinal vasoactivospa
dc.subject.decsNeuropéptidospa
dc.subject.keywordsNeuropeptidesspa
dc.subject.keywordsRabies virusspa
dc.subject.keywordsSensory neuronspa
dc.titleMorphological and biochemical characterisation of sensory neurons infected in vitro with rabies virusspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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