Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study

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dc.contributor.authorSeas, Carlos
dc.contributor.authorGarcia, Coralith
dc.contributor.authorCosta Salles, Mauro José
dc.contributor.authorLabarca, Jaime A.
dc.contributor.authorLuna, Carlos Marcelo
dc.contributor.authorAlvarez Moreno, Carlos Arturo
dc.contributor.authorMejía-Villatoro, Carlos Rodolfo
dc.contributor.authorZurita, Jeannete
dc.contributor.authorGuzmán-Blanco, Manuel
dc.contributor.authorRodríguez-Noriega, Eduardo
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorArias, César A.
dc.contributor.authorĆarcamo, César Paul
dc.contributor.authorGotuzzo, Eduardo H.
dc.contributor.authorBruno, Didier
dc.contributor.authorEfrón, Ernesto D.
dc.contributor.authordel Castillo, Marcelo
dc.contributor.authorDei, Sanatorio Mater
dc.contributor.authorGuimarães, Thaís
dc.contributor.authorCeballos, María Elena
dc.contributor.authorDomínguez, Isabel
dc.contributor.authorRiedel, Gisela
dc.contributor.authorValderrama, Sandra
dc.contributor.authorGualtero, Sandra Milena
dc.contributor.authorSaavedra, Carlos Humberto
dc.contributor.authorTello, Betzabé
dc.contributor.authorGuerrero, Fausto
dc.contributor.authorSilvestre, María Mónica
dc.contributor.authorMorfin-Otero, Rayo
dc.contributor.authorAlcalde, Fray Antonio
dc.contributor.authorHidalgo, José A.
dc.contributor.authorHercilla, Luis
dc.contributor.authorSilva, Marisela
dc.contributor.authorGuzmán, Alfonso José
dc.date.accessioned2020-06-16T18:20:41Z
dc.date.available2020-06-16T18:20:41Z
dc.date.issued2017
dc.description.abstractenglishBackground:Substantial heterogeneity in the epidemiology and management ofStaphylococcus aureusbacter-aemia (SAB) occurs in Latin America. We conducted a prospective cohort study in 24 hospitals from nine LatinAmerican countries.Objectives:To assess the clinical impact of SAB in Latin America.Patients and methods:We evaluated differences in the 30 day attributable mortality among patients with SABdue to MRSA compared with MSSA involving 84 days of follow-up. Adjusted relative risks were calculated using ageneralized linear model.Results:A total of 1030 patients were included. MRSA accounted for 44.7% of cases with a heterogeneous geo-graphical distribution. MRSA infection was associated with higher 30 day attributable mortality [25% (78 of 312)versus 13.2% (48 of 363), adjusted RR: 1.94, 95% CI: 1.38–2.73,P,0.001] compared with MSSA in the multivari-able analysis based on investigators’ assessment, but not in a per-protocol analysis [13% (35 of 270) versus8.1% (28 of 347), adjusted RR: 1.10, 95% CI: 0.75–1.60,P"0.616] or in a sensitivity analysis using 30 day all-cause mortality [36% (132 of 367) versus 27.8% (123 of 442), adjusted RR: 1.09, 95% CI: 0.96–1.23,P"0.179].MRSA infection was not associated with increased length of hospital stay. Only 49% of MSSA bloodstream infec-tions (BSI) received treatment withb-lactams, but appropriate definitive treatment was not associated withlower mortality (adjusted RR: 0.93, 95% CI: 0.70–1.23,P"0.602).Conclusions:MRSA-BSIs in Latin America are not associated with higher 30 day mortality or longer length ofstay compared with MSSA. Management of MSSA-BSIs was not optimal, but appropriate definitive therapy didnot appear to influence mortalityeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/jac/dkx350
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0305-7453
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3193
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalJournal of antimicrobial chemotherapyspa
dc.relation.ispartofseriesJournal of antimicrobial chemotherapy, 0305-7453, Vol. 73, Nro. 1, 2017, p. 212-222spa
dc.relation.urihttps://academic.oup.com/jac/article/73/1/212/4555401
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-10-17
dc.rights.localAcceso abiertospa
dc.subject.decsStaphylococcus aureusspa
dc.subject.decsEstudios de cohortesspa
dc.subject.decsMortalidadspa
dc.titleStaphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort studyspa
dc.title.translatedStaphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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Carlos mares, Coralith Garcia , Mauro J Salles , Jaime Labarca , Carlos Luna , Carlos Alvarez-Moreno , Carlos Mejía-Villatoro , Jeannete Zurita , Manuel Guzmán-Blanco , Eduardo Rodríguez-Noriega_2017.pdf
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