Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300

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dc.contributor.authorCorredor Rozo, Zayda Lorena
dc.contributor.authorMárquez-Ortiz, Ricaurte Alejandro
dc.contributor.authorVanegas, Natasha
dc.contributor.authorEscobar-Pérez, Javier
dc.contributor.authorCastro Cardozo, Betsy Esperanza
dc.contributor.orcidEscobar-Pérez, Javier [0000-0002-0432-6978]
dc.date.accessioned2019-08-27T14:51:31Z
dc.date.available2019-08-27T14:51:31Z
dc.date.issued2017
dc.description.abstractenglishStaphylococcus aureus pandemic clone USA300 has, in addition to its constitutive arginine catabolism (arc) gene cluster, an arginine catabolism mobile element (ACME) carrying another such cluster, which gives this clone advantages in colonisation and infection. Gene arcR, which encodes an oxygen-sensitive transcriptional regulator, is inside ACME and downstream of the constitutive arc gene cluster, and this situation may have an impact on its activation. Different relative expression behaviours are proven here for arcRACME and the arcACME operon compared to the constitutive ones. We also show that the artificially expressed recombinant ArcRACME protein binds to the promoter region of the arcACME operon; this mechanism can be related to a positive feedback model, which may be responsible for increased anaerobic survival of the USA300 clone during infection-related processes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1590/0074-02760160424
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1678-8060
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1658
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdespa
dc.publisher.journalMemorias do instituto Oswaldo Cruzspa
dc.relation.ispartofseriesMemorias do Instituto Oswaldo Cruz, 1678-8060, Vol, 112, Nro. 7, 2017, p.499-503spa
dc.relation.urihttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000700499&lng=en&tlng=en
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf105
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsStaphylococcus aureusspa
dc.subject.decsPrueba de complementación genéticaspa
dc.subject.decsFarmacorresistencia microbianaspa
dc.subject.keywordsUSA300 clonespa
dc.subject.keywordsACMEspa
dc.subject.keywordsTranscriptional activatorspa
dc.titleParticipation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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