Mechanisms of antibiotic resistance

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dc.contributor.authorMunita, Jose M.
dc.contributor.authorArias, Cesar A
dc.date.accessioned2020-07-16T15:43:31Z
dc.date.available2020-07-16T15:43:31Z
dc.date.issued2016
dc.description.abstractenglishEmergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide. Multidrug-resistant organisms have emerged not only in the hospital environment but are now often identified in community settings, suggesting that reservoirs of antibiotic-resistant bacteria are present outside the hospital. The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice. Therefore, understanding the biochemical and genetic basis of resistance is of paramount importance to design strategies to curtail the emergence and spread of resistance and devise innovative therapeutic approaches against multidrug-resistant organisms. In this chapter, we will describe in detail the major mechanisms of antibiotic resistance encountered in clinical practice providing specific examples in relevant bacterial pathogens.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1128%2Fmicrobiolspec.VMBF-0016-2015
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2165-049
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3529
dc.language.isoeng
dc.publisherASM Pressspa
dc.publisher.journalMicrobiology spectrumspa
dc.relation.ispartofseriesMicrobiology spectrum, 2165-0497, Vol. 4, Nro. 2, 2016spa
dc.relation.urihttps://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.VMBF-0016-2015
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-04-08
dc.rights.localAcceso abiertospa
dc.subject.decsFarmacorresistencia microbianaspa
dc.subject.decsSalud públicaspa
dc.subject.decsNoxasspa
dc.titleMechanisms of antibiotic resistancespa
dc.title.translatedMechanisms of antibiotic resistancespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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