Predictors of severe disease in a hospitalized population of children with acute viral lower respiratory tract infections

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dc.contributor.authorPedraza-Bernal, Angela M.
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.contributor.authorAcuña-Cordero, Ranniery
dc.date.accessioned2020-07-15T22:17:45Z
dc.date.available2020-07-15T22:17:45Z
dc.date.issued2015
dc.description.abstractenglishAlthough predictors of severe viral acute lower respiratory infections (ALRIs) in children have been reported, there have been few research studies performed in low‐ and middle‐income countries (LMIC). The aim of the present study was to determine predictors of disease severity in a population of Colombian children <5 years of age with ALRI. In a prospective cohort study, we determined independent predictors of severe ALRI in a hospitalized population of children under 5 years old with ALRI during a 1‐year period. We included both underlying disease conditions and the infecting respiratory viruses as predictor variables of severe disease. We defined severe disease as the necessity of pediatric intensive care unit admission. Of a total of 1,180 patients admitted with a diagnosis of ALRI, 416 (35.3%) were included because they were positive for any kind of respiratory virus. After controlling for potential confounders, it was found that a history of pulmonary hypertension (RR 3.62; CI 95% 2.38–5.52; P  < 0.001) and a history of recurrent wheezing (RR 1.77; CI 95% 1.12–2.79; P  = 0.015) were independent predictors of severe disease. The present study shows that respiratory viruses are significant causes of ALRI in infants and young children in Colombia, a typical tropical LMIC, especially during the rainy season. Additionally, the results of the present study show that clinical variables such as a history of pulmonary hypertension and a history of recurrent wheezing are more relevant for predicting ALRI severity than the infecting respiratory viruses.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/jmv.24394
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0146-6615
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3511
dc.language.isoeng
dc.publisherWiley-Blackwellspa
dc.publisher.journalJournal of medical virologyspa
dc.relation.ispartofseriesJournal of medical virology, 0146-6615, Vol. 88, Nro. 5, 2015spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.24394
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-09-25
dc.rights.localAcceso abiertospa
dc.subject.decsMortalidad Infantilspa
dc.subject.decsEstudios de cohortesspa
dc.subject.decsAdenovirus humanosspa
dc.subject.keywordsAcute respiratory infectionspa
dc.subject.keywordsPediatricsspa
dc.subject.keywordsRespiratory syncytial virusspa
dc.titlePredictors of severe disease in a hospitalized population of children with acute viral lower respiratory tract infectionsspa
dc.title.translatedPredictors of severe disease in a hospitalized population of children with acute viral lower respiratory tract infectionsspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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