Mechanisms of drug resistance: daptomycin resistance

Vista sencilla de ítem
dc.contributor.authorTran, Truc T.
dc.contributor.authorMunita, Jose M.
dc.contributor.authorArias, Cesar A
dc.date.accessioned2020-05-15T19:30:02Z
dc.date.available2020-05-15T19:30:02Z
dc.date.issued2015
dc.description.abstractenglishDaptomycin (DAP) is a cyclic lipopeptide with in vitro activity against a variety of Gram-positive pathogens, including multidrug-resistant organisms. Since its introduction in clinical practice in 2003, DAP has become an important key front-line antibiotic for severe or deep-seated infections caused by Gram-positive organisms. Unfortunately, DAP-resistance (R) has been extensively documented in clinically important organisms such as Staphylococcus aureus, Enterococcus spp, and Streptococcus spp. Studies on the mechanisms of DAP-R in Bacillus subtilis and other Gram-positive bacteria indicate that the genetic pathways of DAP resistance are diverse and complex. However, a common phenomenon emerging from these mechanistic studies is that DAP-R is associated with important adaptive changes in cell wall and cell membrane homeostasis with critical changes in cell physiology. Findings related to these adaptive changes have offered novel insights into the genetics and molecular mechanisms of bacterial cell envelope stress response and the manner in which Gram-positive bacteria cope with the antimicrobial peptide attack and protect vital structures of the cell envelope such as the cell membrane. In this review, we will examine the most recent findings related to the molecular mechanisms of resistance to DAP in relevant Gram-positive pathogens and discuss the clinical implications for therapy against these important bacteria.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/nyas.12948
dc.identifier.issn0077-8923
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2849
dc.language.isoeng
dc.publisherWiley-Blackwellspa
dc.publisher.journalAnnals of the New York Academy of Sciencesspa
dc.relation.ispartofseriesAnnals of the New York Academy of Sciences, 0077-8923, Vol. 1354, Nro. 32, 2015, p. 1-33spa
dc.relation.urihttps://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.12948
dc.rights.creativecommons2015
dc.rights.localAcceso cerradospa
dc.subject.decsHomeostasisspa
dc.subject.decsGram-positivosspa
dc.subject.decsEnterococcusspa
dc.subject.keywordsDaptomycin resistancespa
dc.subject.keywordsBacillus subtilisspa
dc.subject.keywordsStaphylococcus aureusspa
dc.subject.keywordsEnterococcusspa
dc.titleMechanisms of drug resistance: daptomycin resistancespa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Tran T.T., Munita J.M., Arias C.A._2015.pdf
Tamaño:
548.25 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos