Immune responses to dengue and Zika viruses—Guidance for T cell vaccine development

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dc.contributor.authorRoth, Claude
dc.contributor.authorSimon Lorière, Etienne
dc.contributor.authorSakuntabhai, Anavaj
dc.contributor.authorDelgado Tiria, Felix Giovanni
dc.contributor.orcidDelgado Tiria, Felix Giovanni [0000-0001-6685-7507]
dc.contributor.orcidDelgado Tiria, Felix Giovanni [0000-0001-6685-7507]
dc.date.accessioned2019-08-21T19:42:39Z
dc.date.available2019-08-21T19:42:39Z
dc.date.issued2018
dc.description.abstractenglishDespite numerous efforts to identify the molecular and cellular effectors of the adaptive immunity that induce a long-lasting immunity against dengue or Zika virus infection, the specific mechanisms underlying such protective immunity remain largely unknown. One of the major challenges lies in the high level of dengue virus (DENV) seroprevalence in areas where Zika virus (ZIKV) is circulating. In the context of such a pre-existing DENV immunity that can exacerbate ZIKV infection and disease, and given the lack of appropriate treatment for ZIKV infection, there is an urgent need to develop an efficient vaccine against DENV and ZIKV. Notably, whereas several ZIKV vaccine candidates are currently in clinical trials, all these vaccine candidates have been designed to induce neutralizing antibodies as the primary mechanism of immune protection. Given the difficulty to elicit simultaneously high levels of neutralizing antibodies against the different DENV serotypes, and the potential impact of pre-existing subneutralizing antibodies induced upon DENV infection or vaccination on ZIKV infection and disease, additional or alternative strategies to enhance vaccine efficacy, through T cell immunity, are now being considered. In this review, we summarize recent discoveries about cross-reactive B and T cell responses against DENV and ZIKV and propose guidelines for the development of safe and efficient T cell vaccines targeting both viruses.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/ijerph15020385
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1660-4601
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1646
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institutespa
dc.publisher.journalInternational Journal of Environmental Research and Public Healthspa
dc.relation.ispartofseriesInternational Journal of Environmental Research and Public Health, 1661-7827, Vol. 15, num, 2, 2018, p. 385spa
dc.relation.ispartofseriesInternational Journal of Environmental Research and Public Health, 1661-7827, Vol. 15, Nro, 2, 2018, p. 1-12spa
dc.relation.urihttps://www.mdpi.com/1660-4601/15/2/385
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf303
dc.rights.creativecommons2018
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsInmunidad celularspa
dc.subject.decsVacunasspa
dc.subject.decsVirus del denguespa
dc.subject.decsVirus zikaspa
dc.subject.keywordsZika virusspa
dc.subject.keywordsT cell epitopesspa
dc.subject.keywordsVaccinationspa
dc.titleImmune responses to dengue and Zika viruses—Guidance for T cell vaccine developmentspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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