Systemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a bayesian network meta-analysis

Vista sencilla de ítem
dc.contributor.authorCleverton Correa, Rabelo
dc.contributor.authorFeres, Magda
dc.contributor.authorGonçalves, Cristiane
dc.contributor.authorFigueiredo, Luciene C.
dc.contributor.authorFaveri, Marcelo
dc.contributor.authorTu, Yu-Kang
dc.contributor.authorChambrone, Leandro
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-08-11T21:25:15Z
dc.date.available2020-08-11T21:25:15Z
dc.date.issued2015
dc.description.abstractenglishAim: The aim of this study was to assess the effect of systemic antibiotic therapy on the treatment of aggressive periodontitis (AgP). Methods: This study was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE and CENTRAL databases were searched up to June 2014 for randomized clinical trials comparing the treatment of subjects with AgP with either scaling and root planing (SRP) alone or associated with systemic antibiotics. Bayesian network meta-analysis was prepared using the Bayesian random-effects hierarchical models and the outcomes reported at 6-month post-treatment. Results: Out of 350 papers identified, 14 studies were eligible. Greater gain in clinical attachment (CA) (mean difference [MD]: 1.08 mm; p < 0.0001) and reduction in probing depth (PD) (MD: 1.05 mm; p < 0.00001) were observed for SRP + metronidazole (Mtz), and for SRP + Mtz + amoxicillin (Amx) (MD: 0.45 mm, MD: 0.53 mm, respectively; p < 0.00001) than SRP alone/placebo. Bayesian network meta-analysis showed additional benefits in CA gain and PD reduction when SRP was associated with systemic antibiotics. Conclusions: SRP plus systemic antibiotics led to an additional clinical effect compared with SRP alone in the treatment of AgP. Of the antibiotic protocols available for inclusion into the Bayesian network meta-analysis, Mtz and Mtz/ Amx provided to the most beneficial outcomes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/jcpe.12427
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0303-6979
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3766
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalJournal of Clinical Periodontologyspa
dc.relation.ispartofseriesJournal of Clinical Periodontology, 0303-6979, Vol. 42, Nro. 7, 2015, p. 647-657spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.12427
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-07-01
dc.rights.localAcceso abiertospa
dc.subject.keywordsAggressive periodontitisspa
dc.subject.keywordsAmoxicillinspa
dc.subject.keywordsAnti-infective agentsspa
dc.subject.keywordsMetronidazolespa
dc.subject.keywordsRoot planingspa
dc.subject.keywordsSystematic reviewspa
dc.titleSystemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a bayesian network meta-analysisspa
dc.title.translatedSystemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a bayesian network meta-analysisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Correa Rabelo, Cleverton.pdf
Tamaño:
422.18 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos