Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

Vista sencilla de ítem
dc.contributor.authorToh, Seok-Ming
dc.contributor.authorXiong, Liqun
dc.contributor.authorArias, Cesar A.
dc.contributor.authorVillegas, María Virginia
dc.contributor.authorLolans, Karen
dc.contributor.authorQuinn, John
dc.contributor.authorMankin, Alexander S.
dc.contributor.orcidVillegas, María Virginia [0000-0003-1898-9067]
dc.date.accessioned2020-08-31T07:34:05Z
dc.date.available2020-08-31T07:34:05Z
dc.date.issued2007
dc.description.abstractenglishLinezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target site mutations. We have discovered that linezolid resistance in a methicillin-resistant Staphylococcus aureus hospital strain from Colombia is determined by the presence of the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit. The molecular model of the linezolid-ribosome complex reveals localization of A2503 within the drug binding site. The natural function of cfr likely involves protection against natural antibiotics whose site of action overlaps that of linezolid. In the chromosome of the clinical strain, cfr is linked to ermB, a gene responsible for dimethylation of A2058 in 23S rRNA. Coexpression of these two genes confers resistance to all the clinically relevant antibiotics that target the large ribosomal subunit. The association of the ermB/cfr operon with transposon and plasmid genetic elements indicates its possible mobile nature. This is the first example of clinical resistance to the synthetic drug linezolid which involves a natural resistance gene with the capability of disseminating among Gram-positive pathogenic strains.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1365-2958.2007.05744.x
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1365-2958
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3871
dc.language.isoeng
dc.publisher.journalMolecular microbiologyspa
dc.relation.ispartofseriesMolecular microbiology, 1365-2958, Vol. 64, Nro. 6, 2007 p. 1506-1514spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2958.2007.05744.x
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2007
dc.rights.localAcceso abiertospa
dc.subject.decsBacterias grampositivasspa
dc.subject.decsStaphylococcus aureus resistente a meticilinaspa
dc.subject.decsAntiinfecciososspa
dc.titleAcquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolidspa
dc.title.translatedAcquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolidspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Toh_Seok_Ming_2007.pdf
Tamaño:
221.37 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos