Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome

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Lynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdf (803.45 KB)

Fecha

2019

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Publicado en

Journal of infectious diseases, 1537-6613, Vol. 219, Nro. 1, 2019, p. 26-30

Publicado por

Oxford University Press

URI

https://hdl.handle.net/20.500.12495/2069

URL de la fuente

https://academic.oup.com/jid/article/219/1/26/5064749

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Abstract

The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.

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Keywords

Guillain-Barré syndrome, Neutralizing antibody, Flavivirus

Temáticas

Anticuerpos neutralizantes
Virus zika
Virus del dengue

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