Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population

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dc.contributor.authorRomero Infante, Ximena Carolina
dc.contributor.authorUriel Calvo, María Monserrat
dc.contributor.authorRincón Franco, Sara
dc.contributor.authorPorras-Ramírez, Alexandra
dc.contributor.orcidRomero Infante, Ximena Carolina [0000-0002-7040-2705]
dc.contributor.orcidUriel, Montserrat [0000-0001-5987-8633]
dc.contributor.orcidPorras-Ramírez, Alexandra [0000-0002-0800-1388]
dc.contributor.orcidRincón Franco, Sara [0000-0002-4594-9151]
dc.contributor.orcidUriel Calvo, María Monserrat [0000-0001-5987-8633]
dc.contributor.orcidRincón Franco, Sara [0000-0002-4594-9151]
dc.contributor.orcidUriel Calvo, María Monserrat [0000-0001-5987-8633]
dc.contributor.orcidRincón Franco, Sara [0000-0002-4594-9151]
dc.date.accessioned2021-02-25T18:21:09Z
dc.date.available2021-02-25T18:21:09Z
dc.date.issued2021
dc.description.abstractenglishAim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A), in a sample of high risk population for hypertensive disorders. Methods This is a prospective study with 527 singleton pregnancies at 11–14 weeks of gestation. Maternal characteristics, biochemical and biophysical markers were studied to determine the development of preeclampsia and FGR by using receiver operating characteristic curves. Results For preeclampsia, screening, including sociodemographic data plus biophysical markers, had a sensitivity and specificity of 70.3% (CI% 64.3–75.2) and 93.8% (CI% 90.9–96.8), respectively. Combined screening, which includes sociodemographic data, biophysical (mean blood pressure and uterine artery pulsatility index) and biochemical markers (PlGF and PAPP‐A), increased sensitivity and specificity up to 85.5% (CI% 80.2–90.3) and 96.3% (CI% 91.4–98.9), respectively. For FGR, sociodemographic data plus biophysical markers had a sensitivity and specificity of 57.8% (CI% 50.1–63.4) and 80.1% (CI% 74.3–85.9), respectively. Combined screening increased sensitivity and specificity up to 67.2% (CI% 52.1–71.3) and 82.7% (CI% 75.2–90.1), respectively. Conclusion Combined screening for preeclampsia and FGR at 11 to 14 weeks of gestation, which includes maternal characteristics, mean blood pressure, uterine artery pulsatility index, PAPP‐A and PlGF, has higher sensitivity and specificity than other screening options. Therefore, considering all these variables during screening is recommended for a superior opportunity of identifying pregnant women in risk for preeclampsia and FGR, especially in a high‐risk population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/jog.14605
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1447-0756
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5438
dc.language.isoeng
dc.publisherJapan Society of Obstetrics and Gynecologyspa
dc.publisherJohn Wiley & Sons, Incspa
dc.publisher.journalJournal of Obstetrics and Gynaecology Researchspa
dc.relation.ispartofseriesJournal of Obstetrics and Gynaecology Research, 1447-0756, Vol. 47, Nro. 2, 2021, p. 765-773spa
dc.relation.urihttps://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.14605
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_14cb
dc.rights.creativecommons2020-02
dc.rights.localAcceso cerradospa
dc.subject.decsHipertensión inducida en el embarazospa
dc.subject.decsRetardo del crecimiento fetalspa
dc.subject.decsEnfermedades fetalesspa
dc.subject.keywordsFetal growth restrictionspa
dc.subject.keywordsPreeclampsiaspa
dc.subject.keywordsRisk factorsspa
dc.subject.keywordsSensitivityspa
dc.subject.keywordsSpecificityspa
dc.titleComparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationspa
dc.title.translatedComparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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