Emergence and spread of a new community-genotype methicillin-resistant Staphylococcus aureus clone in Colombia

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dc.contributor.authorReyes, Niradiz
dc.contributor.authorRebollo, Juan
dc.contributor.authorPinzón, Hernando
dc.contributor.authorTovar, Catalina
dc.contributor.authorMoreno-Castañeda, Jaime
dc.contributor.authorCorredor Rozo, Zayda Lorena
dc.contributor.authorMoncada, Maria Victoria
dc.contributor.authorVanegas, Natasha
dc.contributor.authorCastro Cardozo, Betsy Esperanza
dc.contributor.authorEscobar-Pérez, Javier
dc.contributor.authorMarquez-Ortiz, Ricaurte Alejandro
dc.contributor.orcidEscobar-Pérez, Javier [0000-0002-0432-6978]
dc.date.accessioned2019-07-25T13:56:20Z
dc.date.available2019-07-25T13:56:20Z
dc.date.issued2017
dc.description.abstractenglishBackground Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) clones are a global concern due to their resistance and increased virulence and their ability to cause infections both hospitalized patients and healthy people in the community. Here, we characterize 32 isolates of a new CG-MRSA clone. These isolates were identified in four cities in Colombia, South America. Methods The isolates were recovered from four different epidemiological and prospective studies that were conducted in several regions of Colombia. Molecular characterizations included multilocus sequence typing; pulsed-field gel electrophoresis; SCCmec, agr and spa typing; and whole-genome sequencing. Results All isolates belonged to ST923 (clonal complex 8), harbouring SCCmec IVa and a spa type t1635 and lacking an arginine catabolism mobile element. The isolates were classified as COL923, were resistant to at least one non-beta-lactam antibiotic, and exhibited high frequencies (>60%) of resistance to macrolides and tetracycline. Using whole-genome sequencing, we found that this new clone harbours novel prophage 3 and beta-island structures and a slightly different pathogenicity island 5. Moreover, isolates belonging to the COL923 clone are grouped in a different clade than USA300 and USA300-LV. Conclusion Our results show the emergence and spread of the COL923 clone in different cities in Colombia. This clone is resistant to several antibiotics and possesses new structures in its mobile genetic elements.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12879-017-2193-3
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1471-2334
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1566
dc.language.isoeng
dc.publisherBiomed Centralspa
dc.publisher.journalBMC Infectious Diseasesspa
dc.relation.ispartofseriesBMC Infectious Diseases, 1471-2334, Vol.17, Nro.108, 2017 p. 1-10spa
dc.relation.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2193-3
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf363
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsFarmacorresistencia microbianaspa
dc.subject.decsClonación de organismosspa
dc.subject.decsStaphylococcus aureus resistente a meticilinaspa
dc.subject.decsEpidemiologíaspa
dc.subject.keywordsMethicillin-resistant staphylococcus aureusspa
dc.subject.keywordsCommunityspa
dc.subject.keywordsNew clonespa
dc.titleEmergence and spread of a new community-genotype methicillin-resistant Staphylococcus aureus clone in Colombiaspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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