Controlled release of an extract of calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: design and in vitro performance

Vista sencilla de ítem
dc.contributor.authorJiménez, Ronald A.
dc.contributor.authorMillán, Diana
dc.contributor.authorSuesca, Edward
dc.contributor.authorSosnik, Alejandro
dc.contributor.authorFontanilla, Marta R.
dc.date.accessioned2020-08-06T19:07:54Z
dc.date.available2020-08-06T19:07:54Z
dc.date.issued2015
dc.description.abstractenglishAiming to develop biological skin dresses with improved performance in the treatment of skin wounds, acellular collagen I scaffolds were modified with polymeric microparticles and the subsequent loading of a hydroglycolic extract of Calendula officinalis flowers. Microparticles made of gelatin-collagen were produced by a water-in-oil emulsion/cross-linking method. Thereafter, these microparticles were mixed with collagen suspensions at three increasing concentrations and the resulting mixtures lyophilized to make microparticle-loaded porous collagen scaffolds. Resistance to enzymatic degradation, ability to associate with the C. officinalis extract, and the extract release profile of the three gelatin-collagen microparticle-scaffold prototypes were assessed in vitro and compared to collagen scaffolds without microparticles used as control. Data indicated that the incorporation of gelatin-collagen microparticles increased the resistance of the scaffolds to in vitro enzymatic degradation, as well as their association with the C. officinalis flower extract. In addition, a sharp decrease in cytotoxicity, as well as more prolonged release of the extract, was attained. Overall results support the potential of these systems to develop innovative dermal substitutes with improved features. Furthermore, the gelatin-collagen mixture represents a low-cost and scalable alternative with high clinical transferability, especially appealing in developing countries.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org//10.1007/s13346-015-0217-3
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2190-3948
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3714
dc.language.isoeng
dc.publisherSpringerspa
dc.publisher.journalDrug Delivery and Translational Researchspa
dc.relation.ispartofseriesDrug Delivery and Translational Research, 2190-3948, Vol. 5, 2015, p. 209–218spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs13346-015-0217-3
dc.rights.accessrightshttps://purl.org/coar/access_right/c_14cb
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.creativecommons2015-02-05
dc.rights.localAcceso cerradospa
dc.subject.keywordsWound healingspa
dc.subject.keywordsCollagen I scaffoldsspa
dc.subject.keywordsCalendula officinalis Lspa
dc.subject.keywordsFlowers extractspa
dc.subject.keywordsPolyphenolsspa
dc.subject.keywordsGelatin-collagenspa
dc.subject.keywordsMicroparticle-loaded skin dressingsspa
dc.titleControlled release of an extract of calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: design and in vitro performancespa
dc.title.translatedControlled release of an extract of calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: design and in vitro performancespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Jiménez, Ronald A..pdf
Tamaño:
3.19 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos