Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study

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dc.contributor.authorPerdomo Lara, Sandra Janneth
dc.contributor.authorBuenahora, María Rosa
dc.contributor.authorÁlvarez, Efraín
dc.contributor.authorGonzalez, Farith
dc.contributor.authorRebolledo Cobos, Martha Leonor
dc.contributor.authorAristizabal, Fabio
dc.contributor.authorColegial, Carlos Humberto
dc.contributor.authorHorta, Alvaro
dc.contributor.authorBustillo, Jairo
dc.contributor.authorDíaz-Báez, David
dc.contributor.authorArdila, Carlos Martín
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidPerdomo Lara, Sandra Janneth [0000-0002-4429-3760]
dc.contributor.orcidDíaz-Báez, David [0000-0001-8890-6250]
dc.date.accessioned2020-03-04T22:08:37Z
dc.date.available2020-03-04T22:08:37Z
dc.date.issued2020
dc.description.abstractenglishBackground: Oral cancer associated with high risk (HPV-HR) human papilloma virus (HPV) has been increasing. HPV-HR has been associated with epithelial dysplasia, however, little information exists on its frequency in epithelial hyperplasia lesions. The aim of this study is to compare HPV genotypes in dysplastic and hyperplastic lesions of oral cavity. Material and Methods: Two hundred and fifty oral lesions: 131 dysplasia and 119 hyperplasia from two regions of Colombia were evaluated. One hundred seventy-four coming from urban area and 104 from a high risk population to oral cancer from a rural area. HPV was identified by qPCR and Twenty-four HPVs genotypes were evaluated by Luminex® technology. Logistic regressions were performed to establish the associations between HPV infections with oral dysplasia. Results: Twenty-eight percent (70/250) of the samples were positives for any HPV and HPV-HRs were more frequently than low risk HPVs. HPV-16 was the most detected genotype (16%) followed by HPV-31, 53, 18 and 45. HPV, HPV-HRs and HPV-16 were only associated with dysplasia in urban area; OR 3.28 (CI 95% 1.49-7.17), OR 7.94 (CI 95% 2.97-21.2) and OR 5.90 (CI 95% 2.05-17). Individuals in rural area showed more HPV and HPV-HRs infection in hyperplasic lesions than urban population. The majority of HPV+ lesions had multi-type of HPV (52/70) and the urban individuals showed more genotypes than rural population. Conclusions: HPV-.HRs are frequently found in hyperplastic and dysplastic epithelial lesions. HPV-HRs and HPV-16 were associated with dysplasia in urban population. Rural high risk population and urban population differ in the frequency and variety of HPV genotypes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/doi:10.4317/medoral.23188
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1698-6946
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1984
dc.language.isoeng
dc.publisherMedicina Oral S.L.spa
dc.publisher.journalMedicina Oral, Patologia Oral y Cirugia Bucalspa
dc.relation.ispartofseriesMedicina Oral, Patologia Oral y Cirugia Bucal, 1698-6946, Vol. 25, Nro. 1, 2020, p. e61-e70spa
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/31880291
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf361
dc.rights.creativecommons2020
dc.rights.localAcceso cerradospa
dc.subject.decsElectroforesis en gel bidimensionalspa
dc.subject.decsEnsayo clínicospa
dc.subject.decsEnfermedades de la bocaspa
dc.subject.keywordsEpithelial dysplasiaspa
dc.subject.keywordsEpithelial hyperplasiaspa
dc.subject.keywordsHPV-genotypesspa
dc.titleHuman papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter studyspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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