The prion-like properties of amyloid-beta peptide and tau: Is there any risk of transmitting alzheimer's disease during neurosurgical interventions?

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dc.contributor.authorPadilla Zambrano, Huber S.
dc.contributor.authorGarcía Ballestas, Ezequiel
dc.contributor.authorQuiñones Ossa, Gabriel A.
dc.contributor.authorSibaja Perez, Andrés E.
dc.contributor.authorAgrawal, Amit
dc.contributor.authorMoscote Salazar, Luis R.
dc.contributor.authorMenéndez González, Manuel
dc.date.accessioned2021-03-05T14:53:19Z
dc.date.available2021-03-05T14:53:19Z
dc.date.issued2020
dc.description.abstractenglishRecent studies have recognized similarities between the peptides involved in the neuropathology of Alzheimer’s disease and prions. The Tau protein and the Amyloid β peptide represent the theoretical pillars of Alzheimer’s disease development. It is probable that there is a shared mechanism for the transmission of these substances and the prion diseases development; this presumption is based on the presentation of several cases of individuals without risk factors who developed dementia decades after a neurosurgical procedure. This article aims to present the role of Aβ and Tau, which underlie the pathophysiologic mechanisms involved in the AD and their similarities with the prion diseases infective mechanisms by means of the presentation of the available evidence at molecular (in-vitro), animal, and human levels that support the controversy on whether these diseases might be transmitted in neurosurgical interventions, which may constitute a wide public health issue.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1567205017666201204164220
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1875-5828
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5554
dc.language.isoeng
dc.publisherBentham Science Publishersspa
dc.publisher.journalCurrent Alzheimer Researchspa
dc.relation.ispartofseriesCurrent Alzheimer Research, 1875-5828, Vol. 17, Nro 9, 2020spa
dc.relation.urihttps://www.eurekaselect.com/188741/article
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.subject.keywordsTransmissionspa
dc.subject.keywordsPrion diseasesspa
dc.subject.keywordsAmyloid-β, Aβ,spa
dc.subject.keywordsNeurosurgeryspa
dc.subject.keywordsCerebral amyloid angiopathyspa
dc.titleThe prion-like properties of amyloid-beta peptide and tau: Is there any risk of transmitting alzheimer's disease during neurosurgical interventions?spa
dc.title.translatedThe prion-like properties of amyloid-beta peptide and tau: Is there any risk of transmitting alzheimer's disease during neurosurgical interventions?spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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