Treatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysis

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dc.contributor.authorMartinez, Jorge Ignacio
dc.contributor.authorSánchez, Hector Fabio
dc.contributor.authorVelandia, Julio Alberto
dc.contributor.authorUrbina, Zulma
dc.contributor.authorFlorián, María Cristina
dc.contributor.authorMartínez, Mauricio Antonio
dc.contributor.authorGiamarellos Bourboulis, Evangelos J.
dc.contributor.authorPino Pinzón, Carmen Juliana
dc.contributor.authorOrtiz, Guillermo
dc.contributor.authorCelis, Edgar
dc.date.accessioned2021-05-21T20:51:46Z
dc.date.available2021-05-21T20:51:46Z
dc.date.issued2021-08
dc.description.abstractenglishThe therapeutic potential of IgM-enriched immunoglobulin preparations (IgGAM) in sepsis remains a field of debate. The use of polyclonal immunoglobulins as adjuvant therapy (Esen & Tugrul, 2009; Kaukonen et al., 2014; Molnár et al., 2013; Taccone et al., 2009) has been shown to improve clinical outcomes in terms of mortality. This study analyze the impact of IgM-enriched IgG (IgGM) as additional immunomodulation. Patients and methods: This is a retrospective registry of 1196 patientswith severe sepsis and septic shock fromnine Intensive Care Units in Colombia, from routine clinical practice; 220 patients treated with IgGAM were registered. Fully matched comparators for severity and type of infection selected among patients non-treated with IgGAM. Mortality after 28 days was 30.5% among IgGAM-treated patients and 40.5% among matched comparators. Results: Multivariate Cox regression analysis showed IgGAM treatment to be the only variable protective from death after 28 days (hazard ratio 0.62; 0.45–0.86; p: 0.004). Results reinforce the importance of IgGAM treatment for favorable outcome after septic shock and are in line with recent published meta-analyses. This study showed that treatment with IgGM in patients with sepsis was an independent modulator of the 28-day associated witha lower mortality.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/J.JCRC.2021.03.015
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0883-9441
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5889
dc.language.isoeng
dc.publisherW.B. Saundersspa
dc.publisher.journalJournal of Critical Carespa
dc.relation.ispartofseriesJournal of Critical Care, 0883-9441, Vol. 64, 2021, p. 120-124.spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0883944121000617
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.subject.keywordsSepsisspa
dc.subject.keywordsSeptic shockspa
dc.subject.keywordsIgM-enriched immunoglobulinsspa
dc.titleTreatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysisspa
dc.title.translatedTreatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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