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dc.contributor.authorPerez, Geovanny F.
dc.contributor.authorPancham, Krishna
dc.contributor.authorHuseni, Shehlanoor
dc.contributor.authorJain, Amisha
dc.contributor.authorRodriguez‐Martinez, Carlos E.
dc.contributor.authorPreciado, Diego
dc.contributor.authorRose, Mary C.
dc.contributor.authorNino, Gustavo
dc.date.accessioned2020-08-10T20:48:47Z
dc.date.available2020-08-10T20:48:47Z
dc.identifier.issn1399-3038spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/3752
dc.description.abstractBackground Rhinovirus (RV ) has been linked to the pathogenesis of asthma. Prematurity is a risk factor for severe RV infection in early life, but is unknown if RV elicits enhanced pro‐asthmatic airway cytokine responses in premature infants. This study investigated whether young children born severely premature (<32 wks gestation) exhibit airway secretion of Th2 and Th17 cytokines during natural RV infections and whether RV ‐induced Th2–Th17 responses are linked to more respiratory morbidity in premature children during the first 2 yrs of life. Methods We measured Th2 and Th17 nasal airway cytokines in a retrospective cohort of young children aged 0–2 yrs with PCR ‐confirmed RV infection or non‐detectable virus. Protein levels of IL ‐4, IL ‐13, TSLP , and IL ‐17 were determined with multiplex immunoassays. Demographic and clinical variables were obtained by electronic medical record (EMR ) review. Results The study comprised 214 children born full term (n = 108), preterm (n = 44) or severely premature (n = 62). Natural RV infection in severely premature children was associated with elevated airway secretion of Th2 (IL ‐4 and IL ‐13) and Th17 (IL ‐17) cytokines, particularly in subjects with history of bronchopulmonary dysplasia. Severely premature children with high RV ‐induced airway IL ‐4 had recurrent respiratory hospitalizations (median 3.65 hosp/yr; IQR 2.8–4.8) and were more likely to have at least one pediatric intensive care unit admission during the first 2 yrs of life (OR 8.72; 95% CI 1.3–58.7; p = 0.02). Conclusions Severely premature children have increased airway secretion of Th2 and Th17 cytokines during RV infections, which is associated with more respiratory morbidity in the first 2 yrs of life.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherWileyspa
dc.relation.ispartofseriesPediatric Allergy and Immunology, 1399-3038, Vol. 26, Nro. 2, 2015, p. 145-152spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/pai.12346spa
dc.titleRhinovirus‐induced airway cytokines and respiratory morbidity in severely premature childrenspa
dc.type.localArtículo de revista
dc.subject.keywordsAsthmaspa
dc.subject.keywordsBronchopulmonary dysplasiaspa
dc.subject.keywordsPrematurityspa
dc.subject.keywordsRhinovirusspa
dc.subject.keywordsTh17spa
dc.subject.keywordsTh2spa
dc.identifier.doihttps://doi.org/10.1111/pai.12346spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalPediatric Allergy and Immunologyspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.identifier.instnameinstname:Universidad El Bosque
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.title.translatedRhinovirus‐induced airway cytokines and respiratory morbidity in severely premature childrenspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abiertospa
dc.date.issued2015-01-30


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