Perfiles de resistencia a fluoroquinolonas en aislamientos clínicos de cocos Gram positivos provenientes de hospitales colombianos, 1994-2004
Cárdenas, Ana María
Díaz, Paula Lucía
Arias, César A.
Biomédica : Revista del Instituto Nacional de Salud, 0120-4157, Vol.28, Num.2, 2008 p. 284-294
Instituto Nacional de Salud
MetadataShow full item record
Introduction. Fluoroquinolones are broad spectrum antibiotics commonly used in the treatmentof infections.Objective. Resistance profiles of coccus bacteria to fluoroquinolones were evaluated in isolatesof Streptococcus pneumoniae, Staphylococcus aureus, coagulase negative staphylococci andEnterococcus spp. The samples were recovered from Colombian hospitals between 1994and 2004.Materials and methods. The minimal inhibitory concentration of ciprofloxacin, moxifloxacinand gatifloxacin was determined in 270 clinical isolates of S. pneumoniae, 348 of S. aureus,176 of coagulase negative staphylococci and 123 of coagulase-negative enterococci. Theminimal inhibitory concentration of levofloxacin was also determined in all isolates of methicillin esistant S. aureus. An agar diffusion susceptibility test with disks of levofloxacin and ofloxacinwas also applied to all isolates of S. pneumoniae.Results. A total of 269 (99.6%) isolates of S. pneumoniae were susceptible to moxifloxacin andgatifloxacin. For levofloxacin and ofloxacin, resistance in S. pneumoniae was found in 1.5%and 8.9% of isolates, respectively. The ciprofloxacin minimal inhibitory concentration was >4μg/ml in 15.9% of pneumococcal isolates. The rates of resistance to ciprofloxacin, gatifloxacinand moxifloxacin in the 348 S. aureus isolates were 55.4%, 54.9% and 52.6%, respectively;increasing to 92.3%, 91.3% and 87.5%, respectively in methicillin resistant isolates. Resistanceto levofloxacin was found in 91.8% of MRSA isolates. The rates of resistance to ciprofloxacin,gatifloxacin and moxifloxacin in coagulase negative staphylococci and vancomycin-susceptibleenterococci were between 25.6% and 31.8%. All vancomycin-resistant enterococci wereresistant to all fluroquinolones tested.Conclusion. The newer fluoroquinolones have maintained effective activity against clinicalisolates of S. pneumoniae. The rates of fluoroquinolone resistance in S. aureus were very high,particularly in methicillin resistant isolates (approaching 100%).
- Artículos