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dc.contributor.authorTéllez Alfonso, Alba N.
dc.contributor.authorVélez, Fernando
dc.contributor.authorUlloa, Juan Carlos
dc.contributor.authorTéllez-Duarte, Miguel A.
dc.date.accessioned2019-07-22T21:42:46Z
dc.date.available2019-07-22T21:42:46Z
dc.identifier.issn1472-6882spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/1555
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBioMed Centralspa
dc.relation.ispartofseriesBMC Complementary and Alternative Medicine, 1472-6882, Vol.15, 2015, p. 10spa
dc.relation.urihttps://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0949-0spa
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleIn vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)spa
dc.typearticlespa
dc.type.localartículospa
dc.subject.decsPruebas de toxicidadspa
dc.subject.decsAntiviralesspa
dc.subject.decsAcciones farmacológicasspa
dc.subject.keywordsAntiviralspa
dc.subject.keywordsRotavirusspa
dc.subject.keywordsAstrovirusspa
dc.subject.keywordsAchyrocline bogotensisspa
dc.identifier.doihttps://doi.org/10.1186/s12906-015-0949-0spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalBMC Complementary and Alternative Medicinespa
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame: Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.cospa
dc.title.translatedIn vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
dc.description.abstractenglishAchyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus activity. Several extracts and fractions phytochemically obtained from A. bogotensis were evaluated initially for their cell toxicity on MA104 and Caco2 cells and then for their anti-rotavirus (RRV) and anti-astrovirus (Yuc8) activity following three strategies: pre-treatment of cells (blocking effect), direct viral activity (virucidal effect) and post-treatment of infected cells (reduction of viral yield post-infection). In addition qualitative chemical studies were developed for the active compounds. Non-toxic concentrations of a fraction obtained exhibited antiviral activity against both viruses characterized by a virucidal effect and by the reduction of the infectious particles produced post-infection. Steroids, sterols, terpenes, phenols, flavonoids and sesquiterpenlactones were identified qualitatively in the active fraction. A. bogotensis contains substances with in vitro antiviral activity against rotavirus and astrovirus. This study confirms their anti-microbial properties and describes by the first time its antiviral activity in vitro.spa
dc.rights.localAcceso abiertospa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf322spa
dc.date.issued2015


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International