Porras Ramírez, AlexandraBarrera Godoy, Rodrigo2024-09-052024-09-052023-08https://hdl.handle.net/20.500.12495/12955Antibiotic resistance, particularly the emergence of carbapenem-resistant Enterobacteriaceae (CRE), poses a significant threat to global public health. This study aimed to develop a predictive model to estimate the clinical risk of CRE infection in patients admitted to an intensive care unit (ICU). A matched case-control study was conducted at a hospital in Bogotá, Colombia, involving 128 patients with CRE infections and 256 controls. The findings showed cardiovascular diseases and diabetes were the most common comorbidities among both groups. Univariate analysis revealed that patients in the case group were more likely to have undergone invasive procedures and medical devices such as central venous catheter insertion, urinary and foley catheter, also had a higher median number of hospitalization days. Moreover, patients with CRE infections had higher APACHE II scores. Previous infections caused by Enterobacteriaceae, hospital-acquired infections, and previous antibiotic treatments were significantly associated with CRE infections. The predictive model was developed using artificial neural networks (ANNs) and incorporated the identified risk factors. The model's performance was evaluated based on sensitivity, specificity, and accuracy, and different ANN configurations were compared. The model showed promise in accurately predicting the clinical risk of CRE infection in ICU patients. This study contributes to the understanding of risk factors associated with CRE infections in ICU settings and provides a practical tool for infection prevention and control strategies. The use of predictive models based on neural networks in public health can revolutionize disease surveillance, resource allocation, and personalized healthcare interventions, ultimately enhancing population health outcomes.application/pdfengAtribución-NoComercial-CompartirIgual 4.0 InternacionalCarbapenem-resistant EnterobacteriaceaeRisk prediction modelIntensive care unitRisk factorsArtificial neural networksTesis/Trabajo de grado - Monografía - MaestríaEnterobacterias resistentes a carbapenemesModelo de predicción de riesgosUnidad de cuidados intensivosFactores de riesgoRedes neuronales artificialesWA 105instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coAcceso abiertoinfo:eu-repo/semantics/openAccesshttps://purl.org/coar/access_right/c_abf2