La otra visión del odontoblasto: una revisión narrativa

dc.contributor.advisorGamboa Martínez, Luis Fernando
dc.contributor.advisorsossa rojas, henry
dc.contributor.authorRodríguez Pérez, Hillary Brigitte
dc.date.accessioned2020-01-22T13:38:11Z
dc.date.available2020-01-22T13:38:11Z
dc.description.abstractEl odontoblasto durante muchos años ha sido descrito como una célula especializada encargada de secretar la matriz extracelular que favorece la biomineralización del complejo pulpo-dentinal, pero en la actualidad las diferentes investigaciones han demostrado que esta célula de origen ectomesenquimal cumple múltiples funciones reguladoras en los procesos fisiopatológicos del complejo dentino-pulpar. Revisar y evidenciar las múltiples funciones del odontoblasto a nivel inmunológico, vascular y neuronal como modulador de las respuestas celulares y moleculares en la regeneración y/o reparación en el complejo pulpo-dentinal. Se realizó una búsqueda electrónica en bases de datos desde enero de 2009 hasta junio de 2018. Las bases de datos que se utilizaron fueron: PUBMED, EMBASE, MEDLINE, Lilacs, Sciente Direct y se incluyeron artículos en inglés. Este estudio examinó y comparó la literatura disponible actualmente acerca de las múltiples funciones del odontoblasto como la nocicepción, la respuesta sensorial a múltiples estímulos externos, la capacidad inmunológica y la participación en procesos inflamatorios, encontrando que esta célula especializada tiene la capacidad de participar y modular los procesos fisiopatológicos tanto de la dentina como de la pulpa.spa
dc.description.abstractenglishThe odontoblast has been describe during years as a specialised cell in charge of secreting the extra-cellular matrix which favours the bio-mineralisation of the dentinal pulp complex. Different investigations have currently shown that this cell, of a ectomesenchyme origin has several regulating functions of physiopathological process of the dentin-pulp complex. to review and evidence the odontoblast’s multiple functions at an immunological, vascular and neuronal level as modulator of cellular and molecular responses in the regeneration and repair of the dentin-pulp complex. An electronic search was carried out of databases from January 2009 to June 2018 and the information used was: PUBMED, EMBASE, MEDLINE, Lilacs, Science Direct including articles in English. The database search yielded 492.157 publications out of which 94 were selected after reviewing the titles, abstract, inclusion and exclusion criteria. This study examined and compared the currently available literature regarding multiple functions of the odontoblast such as nocioception, sensory response to external stimuli, immunological capability and inflammatory processes, finding this specialised cell has the ability to participate and modulate physio-pathological processes of the dentin and pulp.eng
dc.description.degreelevelPregradospa
dc.description.degreenameEspecialista en endodonciaspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1897
dc.language.isospa
dc.publisher.facultyFacultad de Odontologíaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programEspecialización en endodonciaspa
dc.relation.referencesBabb R, Chandrasekaran D, Carvalho V, Sharpe P. Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage. Sci Rep. 2017 Jun 8;7(1):3102.spa
dc.relation.referencesBakri MM, Yahya F, Munawar KMM, Kitagawa J, Hossain MZ. Transient receptor potential vanilloid 4 (TRPV4) expression on the nerve fibers of human dentalpulp is upregulated under inflammatory condition. Arch Oral Biol. 2018 May;89:94-98.spa
dc.relation.referencesBleicher F. Odontoblast Physiology. Experimental Cell Reserch. 2014 Jul; 325 (2): 65-71.spa
dc.relation.referencesBond SR, Naus CC. The pannexins: past and present. Front Physiol. 2014 Feb 19;5:58.spa
dc.relation.referencesByers MR, Westenbroek RE. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels. Arch Oral Biol. 2011 Nov;56(11):1199-220.spa
dc.relation.referencesCho YS, Ryu CH, Won JH, Vang H, Oh SB, Ro JY, Bae YC. Rat odontoblasts may use glutamate to signal dentin injury. Neuroscience. 2016 Oct 29;335:54-63.spa
dc.relation.referencesChung G, Jung SJ, Oh SB. Cellular and molecular mechanisms of dental nociception. J Dent Res. 2013 Nov;92(11):948-55.spa
dc.relation.referencesCooper PR, Chicca IJ, Holder MJ, Milward MR. Inflammation and Regeneration in the Dentin-pulp Complex: Net Gain or Net Loss?. J Endod. 2017 Sep; 43(9S):S87-S94.spa
dc.relation.referencesCooper PR, Holder MJ, Smith AJ. Inflammation and regeneration in the dentin-pulp complex: a double-edged sword. J Endod. 2014 Apr;40(4 Suppl):S46-51.spa
dc.relation.referencesCouve E, Osorio R, Schmachtenberg O. The Amazing Odontoblast: Activity, Autophagy, and Aging. J Dent Res. 2013 Jun; 92 (9): 765-772.spa
dc.relation.referencesCouve E, Osorio R, Schmachtenberg O. Mitochondrial autophagy and lipofuscin accumulation in aging odontoblasts. J Dent Res. 2012 Jul;91(7):696-701.spa
dc.relation.referencesCouve E, Schmachtenberg O. Autophagic activity and aging in human odontoblasts. J Dent Res. 2011 Apr;90(4):523-8.spa
dc.relation.referencesEgbuniwe O, Grover S, Duggal AK, Mavroudis A, Yazdi M, Renton T, Di Silvio L, Grant AD. TRPA1 and TRPV4 activation in human odontoblasts stimulates ATP release. J Dent Res. 2014 Sep;93(9):911-7.spa
dc.relation.referencesEl Karim I, McCrudden MT, Linden GJ, Abdullah H, Curtis TM, McGahon M, About I, Irwin C, Lundy FT. TNF-α-induced p38MAPK activation regulates TRPA1 and TRPV4 activity in odontoblast-like cells. Am J Pathol. 2015 Nov; 185(11): 2994-3002.spa
dc.relation.referencesEl Karim IA, McCrudden MT, McGahon MK, Curtis TM, Jeanneau C, Giraud T, Irwin CR, Linden GJ, Lundy FT, About I. Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells. J Endod. 2016 Apr; 42(4):589-95.spa
dc.relation.referencesEl Karim LA, Linden GJ, Curtis TM, About I, McGahon MK, Irwin CR, Lundy FT. Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentinspa
dc.relation.referencesFarges JC , Keller JF , Carrouel F , Durand SH , Romeas A, Bleicher F, Lebecque S , Staquet MJ . Odontoblasts in the dental pulp immune response. J Exp Zool B Mol Dev Evol. 2009 Jul; 312B(5):425-36.spa
dc.relation.referencesFarges JC Bellanger A, Ducret M, Aubert-Foucher E, Richard B, Alliot-Licht B, Bleicher F, Carrouel F. Human odontoblast-like cells produce nitric oxide with antibacterial activity upon TLR2 activation. Front Physiol. 2015 Jun 23;6:185.spa
dc.relation.referencesFarges J-C, Carrouwl F, Keller J-F, Baudouin C, Msika P, Bleicher F, Staquet M-J. Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement. Immunobiology, 2011 Apr; 216 (4): 513-517.spa
dc.relation.referencesFarges JC, Alliot-Licht B, Baudouin C, Msika P, Bleicher F, Carrouel F. Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria. Front Physiol. 2013 Nov 11;4:326.spa
dc.relation.referencesFarges JC, Alliot-Licht B, Renard E, Ducret M, Gaudin A, Smith AJ, Cooper PR. Dental Pulp Defence and Repair Mechanisms in Dental Caries. Mediators Inflamm. 2015 Oct; 230251.spa
dc.relation.referencesFu D, Song F, Sun H, Pei D, Wang Y, Lei J, Huang C. Expression of Pannexin3 in human odontoblast-like cells and its hemichannel function in mediating ATP release. Arch Oral Biol. 2015 Oct;60(10):1510-6.spa
dc.relation.referencesGoldberg M, Njeh A, Uzunoglu E. Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration?. Mediators Inflamm. 2015 Oct; 347649.spa
dc.relation.referencesHe W, Qu T, Yu Q, Wang Z, Wang H, Zhang J, Smith AJ. Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloiddifferentiating factor 88, nuclear factor-kappa B, and mitogen activated protein kinase path ways in odontoblast cells. J Endod. 2012 Apr; 38(4):464-9.spa
dc.relation.referencesHe W, Wang Z, Luo Z, Yu Q, Jiang Y, Zhang Y, Zhou Z, Smith AJ, Cooper PR. LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway. J Cell Physiol. 2015 Mar;230(3):554-61.spa
dc.relation.referencesHorst OV, Horst JA, Samudrala R, Dale BA. Caries induced cytokine network in the odontoblast layer of human teeth. BMC Immunol. 2011 Jan; 24;12:9.spa
dc.relation.referencesHorst OV, Tompkins KA, Coats SR, Braham PH, Darveau RP, Dale BA. TGF-β1 Inhibits TLR-mediated Odontoblast Responses to Oral Bacteria. J Dent Res. 2009 Apr; 88(4):333-8.spa
dc.relation.referencesHosokawa Y, Hirao K, Yumoto H, Washio A, Nakanishi T, Takegawa D, Kitamura C, Matsuo T. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity. Biomed Res Int. 2016 Sep; 9325436.spa
dc.relation.referencesIchikawa H, Kim HJ, Shuprisha A, Shikano T, Tsumura M, Shibukawa Y, Tazaki M. Voltage-dependent sodium channels and calcium-activated potassium channels in human odontoblasts in vitro. J Endod. 2012 Oct;38(10):1355-62.spa
dc.relation.referencesIkeda E, Goto T, Gunjigake K, Kuroishi K, Ueda M, Kataoka S, Toyono T, Nakatomi M, Seta Y, Kitamura C, Nishihara T, Kawamoto T. Expression of Vesicular Nucleotide Transporter in Rat Odontoblasts. Acta Histochem Cytochem. 2016 Feb 27;49(1):21-8.spa
dc.relation.referencesIkeda H, Suda H. Odontoblastic syncytium through electrical coupling in the human dental pulp. J Dent Res. 2013 Apr;92(4):371-5.spa
dc.relation.referencesIwamoto T , Nakamura T , Ishikawa M , Yoshizaki K , Sugimoto A , Ida-Yonemochi H , Ohshima H , Saito M , Yamada Y , Fukumoto S. Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities. PLoS One. 2017 May 11;12(5):e0177557.spa
dc.relation.referencesJang JH, Shin HW, Lee JM, Lee HW, Kim EC, Park SH. An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp. Mediators Inflamm. 2015 Oct;794143.spa
dc.relation.referencesJardín I, Lopez JJ, Diez R, Sánchez-Collado J, Cantonero C, Albarrán L, Woodard GE, Redondo PC, Salido GM, Smani T, Rosado JA. TRPs in Pain Sensation. Front Physiol. 2017 Jun 9;8:392.spa
dc.relation.referencesJiang W, Lv H, Wang H, Wang D, Sun S, Jia Q, Wang P, Song B, Ni L. Activation of the NLRP3/caspase 1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts. Cell Tissue Res. 2015 Aug; 361(2):541-55.spa
dc.relation.referencesKawashima N, Okiji T. Odontoblasts: Specialized hard-tissue-forming cells in the dentin-pulp complex. Congenital Anomalies. 2016 Abr; 56, 144–153.spa
dc.relation.referencesKeller JF, Carrouel F, Colomb E, Durand SH, Baudouin C, Msika P, Bleicher F, Vincent C, Staquet M.J, Farges J.C. Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells. Immunobiology. 2010 Jan. 215: 53-59.spa
dc.relation.referencesKeller JF, Carrouel F, Staquet MJ, Kufer TA, Baudouin C, Msika P, Bleicher F, Farges JC. Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells. Innate Immun. 2011 Feb; 17(1):29-34.spa
dc.relation.referencesKhatibi Shahidi M, Krivanek J, Kaukua N, Ernfors P, Hladik L, Kostal V, Masich S, Hampl A, Chubanov V, Gudermann T, Romanov RA, Harkany T, Adameyko I, Fried K. Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts. J Dent Res. 2015 Jul;94(7):945-54.spa
dc.relation.referencesKim JH, Woo SM, Choi NK, Kim WJ, Kim SM, Jung JY. Effect of Platelet-rich Fibrin on Odontoblastic Differentiation in Human Dental Pulp Cells Exposed to Lipopolysaccharide. J Endod. 2017 Mar;43(3):433-438.spa
dc.relation.referencesKim YS, Jung HK, Kwon TK, Kim CS, Cho JH, Ahn DK, Bae YC. Expression of transient receptor potential ankyrin 1 in human dental pulp. J Endod. 2012 Aug;38(8):1087-92.spa
dc.relation.referencesKimura M, Nishi K, Higashikawa A, Ohyama S, Sakurai K, Tazaki M, Shibukawa Y. High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release Activated Ca2+ Channels in Rat Odontoblasts. Front Physiol. 2018 May 1;9:443.spa
dc.relation.referencesKimura M, Sase T, Higashikawa A, Sato M, Sato T, Tazaki M, Shibukawa Y. High pH-Sensitive TRPA1 Activation in Odontoblasts Regulates Mineralization. J Dent Res. 2016 Aug;95(9):1057-64.spa
dc.relation.referencesKojima Y, Kimura M, Higashikawa A, Kono K, Ando M, Tazaki M, Shibukawa Y. Potassium Currents Activated by Depolarization in Odontoblasts. Frontiers in Physiology. 2017 Dec; 1078 (8): 1-10.spa
dc.relation.referencesKojima Y, Higashikawa A, Kimura M, Sato M, Mochizuki H, Ogura K, Sase T, Shinya A, Kobune K, Furuya T, Sato T, Shibukawa Y, Tazaki M. Depolarization-induced Intracellular Free Calcium Concentration Increases Show No Desensitizing Effect in Rat Odontoblasts. Bull Tokyo Dent Coll. 2015;56(2):131-4spa
dc.relation.referencesKorkmaz Y, Lang H, Beikler T, Cho B, Behrends S, Bloch W, Addicks K, Raab WH. Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts. J Dent Res. 2011 Apr;90(4):517-22.spa
dc.relation.referencesKrivanek J, Adameyko I, Fried K. Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth. Frontiers in Physiology. 2017 Jun; 376 (8): 1-10.spa
dc.relation.referencesKwon M, Baek SH, Park CK, Chung G, Oh SB. Single-cell RT-PCR and immunocytochemical detection of mechanosensitive transient receptor potential channels in acutely isolated rat odontoblasts. Arch Oral Biol. 2014 Dec;59(12):1266-71.spa
dc.relation.referencesLe Fur-Bonnabesse A, Bodéré C, Hélou C, Chevalier V, Goulet JP. Dental pain induced by an ambient thermal differential: pathophysiological hypothesis. J Pain Res. 2017 Dec 15;10:2845-2851.spa
dc.relation.referencesLee BM, Jo H, Park G, Kim YH, Park CK, Jung SJ, Chung G, Oh SB. Extracellular ATP Induces Calcium Signaling in Odontoblasts. J Dent Res. 2017 Feb;96(2):200-207.spa
dc.relation.referencesLi Y , Wang H, Pei F, Chen Z, Zhang L. FoxO3a Regulates Inflammation-induced Autophagy in Odontoblasts. J Endod. 2018 May; 44 (5): 786-791.spa
dc.relation.referencesLiu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF. Expression of ecto-ATPase NTPDase2 in human dental pulp. J Dent Res. 2012 Mar;91(3):261-7.spa
dc.relation.referencesLiu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT. External Dentin Stimulation Induces ATP Release in Human Teeth. J Dent Res. 2015 Sep;94(9):1259-66.spa
dc.relation.referencesLiu Y, Gao Y, Zhan X, Cui L, Xu S, Ma D, Yue J, Wu B, Gao J. TLR4 activation by lipopolysaccharide and Streptococcus mutans induces differential regulation of proliferation and migration in human dental pulp stem cells. J Endod. 2014 Sep; 40(9):1375-81.spa
dc.relation.referencesMagloire H, Couble ML, Thivichon-Prince B, Maurin JC, Bleicher F. Odontoblast: a mechano-sensory cell. J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):416-24.spa
dc.relation.referencesMaurin JC, Couble ML, Thivichon-Prince B, Magloire H. [Odontoblast: a key cell involved in the perception of dentinal pain]. Med Sci (Paris). 2013 Mar;29(3):293-9.spa
dc.relation.referencesNishiyama A, Sato M, Kimura M, Intercellular signal communication among. Cell Calcium. 2016 Nov; 60 (5): 341-355.spa
dc.relation.referencesPääkkönen V, Rusanen P, Hagström J, Tjäderhane L. Mature human odontoblasts express virus-recognizing toll-like receptors. Int Endod J. 2014 Oct;47(10):934-41.spa
dc.relation.referencesPei F, Lin H, Liu H, Li L, Zhang L, Chen Z. Dual role of autophagy in lipopolysaccharide-induced preodontoblastic cells. J Dent Res. 2015 Jan;94(1):175-82.spa
dc.relation.referencesPei F, Wang HS, Chen Z, Zhang L. Autophagy regulates odontoblast differentiation by suppressing NF-κB activation in an inflammatory environment. Cell Death Dis. 2016 Mar 3;7:e2122.spa
dc.relation.referencesQin W, Gao X, Ma T, Weir M.D, Zou J, Song B, Lin Z, Schneider A, Xu H.K. Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling. 2018 Abr; 44 (4): 576-584.spa
dc.relation.referencesQue K, He D, Jin Y, Wu L, Wang F, Zhao Z, Yang J, Deng J. Expression of Cannabinoid Type 1 Receptors in Human Odontoblast Cells. J Endod. 2017 Feb;43(2):283-288.spa
dc.relation.referencesRenard E, Gaudin A, Bienvenu G, Amiaud J, Farges JC, Cuturi MC, Moreau A, Alliot-Licht B. Immune Cells and Molecular Networks in Experimentally Induced Pulpitis. J Dent Res. 2016 Feb;95(2):196-205.spa
dc.relation.referencesRicucci D, Loghin S, Lin LM, Spångberg LS, Tay FR. Is hard tissue formation in the dental pulp after the death of the primary odontoblasts a regenerative or a reparative process? J Dent. 2014 Sep;42(9):1156-70.spa
dc.relation.referencesSato M, Furuya T, Kimura M, Kojima Y, Tazaki M, Sato T, Shibukawa Y. Intercellular Odontoblast Communication via ATP Mediated by Pannexin-1 Channel and Phospholipase C-coupled Receptor Activation. Front Physiol. 2015 Nov 10;6:326.spa
dc.relation.referencesSato M, Ogura K, Kimura M, Nishi K, Ando M, Tazaki M, Shibukawa Y. Activation of Mechanosensitive Transient Receptor Potential/Piezo Channels in Odontoblasts Generates Action Potentials in Cocultured Isolectin B4-negative Medium sized Trigeminal Ganglion Neurons. J Endod. 2018 Jun;44(6):984-991.e2.spa
dc.relation.referencesSato M, Sobhan U, Tsumura M, Kuroda H, Soya M, Masamura A, Nishiyama A, Katakura A, Ichinohe T, Tazaki M, Shibukawa Y. Hypotonic-induced stretching of plasma membrane activates transient receptor potential vanilloid channels and sodium-calcium exchangers in mouse odontoblasts. J Endod. 2013 Jun;39(6):779-87.spa
dc.relation.referencesShibukawa Y, Sato M, Kimura M, Sobhan U, Shimada M, Nishiyama A, Kawaguchi A, Soya M, Kuroda H, Katakura A, Ichinohe T, Tazaki M. Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction. Pflugers Arch. 2015 Apr;467(4):843-63.spa
dc.relation.referencesShiozaki Y, Sato M, Kimura M, Sato T, Tazaki M, Shibukawa Y. Ionotropic P2X ATP Receptor Channels Mediate Purinergic Signaling in Mouse Odontoblasts. Front Physiol. 2017 Jan 20;8:3.spa
dc.relation.referencesSolé-Magdalena A, Martínez-Alonso M, Coronado CA, Junquera LM, Cobo J, Vega JA. Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels. Ann Anat. 2018 Jan;215:20-29spa
dc.relation.referencesSolé-Magdalena A, Revuelta EG, Menénez-Díaz I, Calavia MG, Cobo T, García-Suárez O, Pérez-Piñera P, De Carlos F, Cobo J, Vega JA. Human odontoblasts express transient receptor protein and acid sensing ion channel mechano sensor proteins. Microsc Res Tech. 2011 May;74(5):457-63.spa
dc.relation.referencesSon AR, Yang YM, Hong JH, Lee SI, Shibukawa Y, Shin DM. Odontoblast TRP channels and thermo/mechanical transmission. J Dent Res. 2009 Nov;88(11):1014-9.spa
dc.relation.referencesSong F, Sun H, Wang Y, Yang H, Huang L, Fu D, Gan J, Huang C. Pannexin3 inhibits TNF-α-induced inflammatory response by suppressing NF-κB signalling pathway in human dental pulp cells. J Cell Mol Med. 2017 Mar; 21(3):444-455.spa
dc.relation.referencesSong Y, Cao P, Gu Z, Xiao J, Lian M, Huang D, Xing J, Zhang Y, Feng X, Wang C. The Role of Neuropilin-1–FYN Interaction in Odontoblast Differentiation of Dental Pulp Stem Cells. Cell Reprogram. 2018 Apr; 20(2):117-126.spa
dc.relation.referencesSong Z, Chen L, Guo J, Qin W, Wang R, Huang S, Yang X, Tian Y, Lin Z. The Role of Transient Receptor Potential Cation Channel, Subfamily C, Member 1 inspa
dc.relation.referencesSong Z, Lin Z, He F, Jiang L, Qin W, Tian Y, Wang R, Huan. NLRP3 is expressed in human dental pulp cells and tissues. J Endod. 2012 Dec;38(12):1592-7spa
dc.relation.referencesStaquet MJ, Carrouel F, Keller JF, Baudouin C, Msika P, Bleicher F, Kufer TA, Farges JC. Pattern-recognition receptors in pulp defense. Adv Dent Res. 2011 Jul; 23(3):296-301.spa
dc.relation.referencesTakanchea J, Kima J-S, Kima J-E, Hanb S-H, Yia H-K. Schisandrin C enhances odontoblastic differentiation through autophagy and mitochondrial biogenesis in human dental pulp cells. Archives of Oral Biology. 2018 Jan. 88:60–66.spa
dc.relation.referencesTazawa K, Ikeda H, Kawashima N, Okiji T. Transient receptor potential melastatin (TRPM) 8 is expressed in freshly isolated native human odontoblasts. Arch Oral Biol. 2017 Mar;75:55-61.spa
dc.relation.referencesTokuda M, Tatsuyama S, Fujisawa M, Morimoto-Yamashita Y, Kawakami Y, Shibukawa Y, Torii M. Dentin and pulp sense cold stimulus. Med Hypotheses. 2015 May;84(5):442-4.spa
dc.relation.referencesTorres-da-Silva KR, Tessarin GWL, Dias CA, Guiati IZ, Ervolino E, Gonçalves A, Beneti IM, Lovejoy DA, Casatti CA. Teneurin-2 presence in rat and human odontoblasts. PLoS One. 2017 Sep 19;12(9):e0184794.spa
dc.relation.referencesTsumura M, Sobhan U, Muramatsu T, Sato M, Ichikawa H, Sahara Y, Tazaki M, Shibukawa Y. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. Cell Calcium. 2012 Aug;52(2):124-36.spa
dc.relation.referencesTsumura M, Sobhan U, Sato M, Shimada M, Nishiyama A, Kawaguchi A, Soya M, Kuroda H, Tazaki M, Shibukawa Y. Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. PLoS One. 2013 Dec 16;8(12):e82233.spa
dc.relation.referencesUtreras E, Prochazkova M, Terse A, Gross J, Keller J, Iadarola MJ, Kulkarni AB. TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain. 2013 May; 13;9:24.spa
dc.relation.referencesWang W, Yi X, Ren Y, Xie Q. Effects of Adenosine Triphosphate on Proliferation and Odontoblastic Differentiation of HumanDental Pulp Cells. J Endod. 2016 Oct;42(10):1483-9.spa
dc.relation.referencesWen W, Que K, Zang C, Wen J, Sun G, Zhao Z, Li Y. Expression and distribution of three transient receptor potential vanilloid(TRPV) channel proteins in human odontoblast-like cells. J Mol Histol. 2017 Dec;48(5-6):367-377.spa
dc.relation.referencesWetsel WC. Sensing hot and cold with TRP channels. Int J Hyperthermia. 2011;27(4):388-98.spa
dc.relation.referencesWon J, Vang H, Kim JH, Lee PR, Kang Y, Oh SB. TRPM7 Mediates Mechanosensitivity in Adult Rat Odontoblasts. J Dent Res. 2018 Feb 1:22034518759947.spa
dc.relation.referencesYang CS, Shin DM, Jo EK. The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases. Int Neurourol J. 2012 Mar;16(1): 2-12.spa
dc.relation.referencesYi X, Wang W, Xie Q. Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells. Biochem Biophys Res Commun. 2018 Mar 11;497(3):850-856.spa
dc.relation.referencesYumoto H, Hirao K, Hosokawa Y, Kuramoto H, Takegawa D, Nakanishi T. The roles of odontoblasts in dental pulp innate immunity. JADS. 2018 Mar; 194.spa
dc.relation.referencesZhang J, Zhu QL, Huang P, Yu Q, Wang ZH, Cooper PR, Smith AJ, He W. CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERKand NF-κB signalling pathways in odontoblast cells. Int Endod J. 2013 Jul;46(7):666-74.spa
dc.relation.referencesZhang L, Chen Z . Autophagy in the dentin-pulp complex against inflammation. Oral Dis. 2018 Mar; 24(1-2):11-13.spa
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons2018
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.nlmWU 230spa
dc.titleLa otra visión del odontoblasto: una revisión narrativaspa
dc.title.translatedThe other perspective of the odontoblast. A narrative revisionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1fspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localTrabajo de gradospa
dc.type.localTesis/Trabajo de grado - Monografía - Doctoradospa

Archivos

Bloque original
Mostrando 1 - 2 de 2
Cargando...
Miniatura
Nombre:
Rodríguez_Pérez_Hillary_Brigitte_2018.pdf
Tamaño:
1.53 MB
Formato:
Adobe Portable Document Format
Descripción:
No hay miniatura disponible
Nombre:
Rodríguez_Pérez_Hillary_Brigitte_2018_Carta_autorizacion.pdf
Tamaño:
1.61 MB
Formato:
Adobe Portable Document Format
Descripción:
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción: