Plantas colombianas como fuente de principios activos con potencial actividad antiproliferativa frente a carcinoma hepatocelular: una revisión narrativa de la literatura

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dc.contributor.advisorMorantes Medina, Sandra Johanna
dc.contributor.advisorDelgado Tiria, Félix Giovanni
dc.contributor.authorPretel Luengas, Geraldine
dc.date.accessioned2025-05-16T16:54:25Z
dc.date.available2025-05-16T16:54:25Z
dc.date.issued2025-04
dc.description.abstractColombia, como segundo país con mayor biodiversidad a nivel mundial, representa una fuente invaluable de nuevos principios activos con potencial terapéutico frente a carcinoma hepatocelular, un tipo de cáncer que aunque no es de los más frecuentes, es necesario investigar nuevas opciones de tratamiento. Este estudio se centró en recopilar y analizar información bibliográfica sobre plantas colombianas con potencial actividad antiproliferativa frente a carcinoma hepatocelular. Empleando algunos elementos de la metodología PRISMA, se identificaron 52 especies de plantas de las cuales, solo 12 demostraron actividad citotóxica significativa frente a hepatocarcinomas. La mayor concentración de estudios se encontró en el departamento de Santander, donde se priorizaron los aceites esenciales, seguidos de extractos y fracciones obtenidas de hojas+tallos. Destacando que, la planta Lippia alba mostró valores de CI50 prometedores (4,3 µg/mL), mientras que la fracción de Annona spraguei Saff. presentó una alta actividad antiproliferativa a 24 horas (CI50 de 11 µg/mL), Estos hallazgos resaltan el potencial de las plantas colombianas en la búsqueda de nuevos agentes terapéuticos contra el cáncer hepático.
dc.description.abstractenglishColombia, as the second most biodiverse country in the world, represents an invaluable source of new active principles with therapeutic potential against hepatocellular carcinoma, a type of cancer that, although it is not one of the most frequent, it is necessary to investigate new treatment options. This study focused on collecting and analyzing bibliographic information on Colombian plants with potential antiproliferative activity against hepatocellular carcinoma. Using some elements of the PRISMA methodology, 52 plant species were identified, of which only 12 showed significant cytotoxic activity against hepatocellular carcinoma. The highest concentration of studies was found in the department of Santander, where priority was given to essential oils, followed by extracts and fractions obtained from leaves + stems. The Lippia alba plant showed promising CI50 values (4.3 µg/mL), while the Annona spraguei Saff. fraction presented high antiproliferative activity at 24 hours (CI50 of 11 µg/mL). These findings highlight the potential of Colombian plants in the search for new therapeutic agents against liver cancer.
dc.description.degreelevelPregradospa
dc.description.degreelevelQuímico Farmacéuticospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/14371
dc.language.isoes
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programQuímica Farmacéuticaspa
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dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPlantas medicinales
dc.subjectBioprospección
dc.subjectAgentes antineoplásicos
dc.subjectCarcinoma hepatocelular
dc.subject.ddc615.19
dc.subject.keywordsMedicinal plants
dc.subject.keywordsBioprospecting
dc.subject.keywordsAntineoplastic agents
dc.subject.keywordsHepatocellular carcinoma
dc.titlePlantas colombianas como fuente de principios activos con potencial actividad antiproliferativa frente a carcinoma hepatocelular: una revisión narrativa de la literatura
dc.title.translatedColombian plants as a source of active principles with potential antiproliferative activity against hepatocellular carcinoma: a narrative review of the literature
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Pregrado

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