Estudio del impacto de los parámetros del proceso de granulación húmeda sobre los atributos farmacotécnicos de gránulos de Sílice

Gómez Jerez, Yudy Alexandra

Estudio del impacto de los parámetros del proceso de granulación húmeda sobre los atributos farmacotécnicos de gránulos de Sílice

dc.contributor.advisor	Jimenez Cruz, Ronald Andres
dc.contributor.author	Gómez Jerez, Yudy Alexandra
dc.date.accessioned	2025-05-16T20:39:42Z
dc.date.available	2025-05-16T20:39:42Z
dc.date.issued	2025-05
dc.description.abstract	La granulación húmeda es un proceso crucial en la fabricación farmacéutica ya que influye en las propiedades físicas de los gránulos y, por tanto, en la calidad del producto final. Este estudio se centró en el procesamiento de gránulos de Sílice (dióxido de silicio) utilizando un granulador oscilante, variando parámetros como la concentración de aglutinante PVP K30, la velocidad de oscilación entre 55, 155,305 rpm y el tamaño de malla 16 y 20. Se emplearon varias metodologías para caracterizar los gránulos, incluyendo la friabilidad, dureza, ángulo de reposo, índice de Carr e índice de Hausner. Los resultados obtenidos indican que un aumento de la concentración de PVP K30 y de la velocidad de oscilación mejoraba la cohesión y la resistencia mecánica de los gránulos. Además, los gránulos presentaban formas redondas y una porosidad moderada, lo que favorecía su fluidez. Por tanto, la optimización de los parámetros de granulación puede conducir a la producción de formulaciones farmacéuticas más eficientes y eficaces, contribuyendo así a la mejora de los procesos de fabricación en la industria.
dc.description.abstractenglish	Wet granulation is a crucial process in pharmaceutical manufacturing as it influences the physical properties of the granules and thus the quality of the final product. This study focused on the processing of Silica (silicon dioxide) granules using an oscillating granulator, varying parameters such as PVP K30 binder concentration, oscillation speed between 55, 155,305 rpm and mesh size 16 and 20. Several methodologies were employed to characterize the granules, including friability, hardness, angle of repose, Carr's index and Hausner's index. The results obtained indicate that an increase in PVP K30 concentration and oscillation rate improved the cohesion and mechanical strength of the granules. In addition, the granules exhibited round shapes and moderate porosity, which favored their flowability. Therefore, the optimization of granulation parameters can lead to the production of more efficient and effective pharmaceutical formulations, thus contributing to the improvement of manufacturing processes in the industry.
dc.description.degreelevel	Pregrado	spa
dc.description.degreelevel	Químico Farmacéutico	spa
dc.format.mimetype	application/pdf
dc.identifier.instname	Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/14376
dc.language.iso	es
dc.publisher.faculty	Facultad de Ciencias	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Química Farmacéutica	spa
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dc.rights	Attribution-NonCommercial-ShareAlike 4.0 International	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	https://purl.org/coar/access_right/c_abf2
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject	Granulación húmeda
dc.subject	PVP K30
dc.subject	Granulador oscilante
dc.subject	Cohesión
dc.subject	Resistencia mecánica
dc.subject	Fluidez
dc.subject	Optimización de parámetros
dc.subject.ddc	615.19
dc.subject.keywords	Wet granulation
dc.subject.keywords	PVP K30
dc.subject.keywords	Oscillating granulator
dc.subject.keywords	Cohesion
dc.subject.keywords	Mechanical resistance
dc.subject.keywords	Fluency
dc.subject.keywords	Parameter optimization
dc.title	Estudio del impacto de los parámetros del proceso de granulación húmeda sobre los atributos farmacotécnicos de gránulos de Sílice
dc.title.translated	Study of the impact of wet granulation process parameters on the pharmacotechnical attributes of silica granules
dc.type.coar	https://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/bachelorThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Pregrado