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Case report: desensitization of hypersensitivity against the antisense oligonucleotide volanesorsen

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dc.contributor.authorIsaac, Rafael H.
dc.contributor.authorGonzalez-Devia, Deyanira
dc.contributor.authorMendivil, Carlos O.
dc.contributor.authorChapman, Edgardo
dc.date.accessioned2023-07-25T17:06:32Z
dc.date.available2023-07-25T17:06:32Z
dc.date.issued2023
dc.description.abstractenglishFamilial chylomicronemia syndrome (FCS) is a rare autosomal recessive metabolic disorder that causes extremely elevated plasma triglyceride levels, with limited therapeutic options. Volanesorsen is an antisense oligonucleotide approved for its treatment. A 24-year-old woman with genetically diagnosed FCS secondary to a pathogenic variant in APOA5 and a history of recurrent hypertriglyceridemia-induced pancreatitis episodes was being treated with volanesorsen, 285 mg every 2 weeks. Treatment with volanesorsen achieved normalization of triglycerides to <200 mg/dl. However, after the fifth dose of the medication, the patient developed urticaria and volanesorsen was discontinued. In the absence of alternative pharmacological treatments, the patient received a novel desensitization protocol for volanesorsen that allowed continuation of therapy, without evidence of hypersensitivity reactions after subsequent administrations. FCS requires aggressive multimodal therapy and close follow-up. Volanesorsen has shown great efficacy, but a significant rate of discontinuation due to side effects has been observed. Here, the patient presented an immediate hypersensitivity reaction to volanesorsen, but the provision of a desensitization protocol was effective, facilitating continued treatment and impacting the survival and quality of life of the patient.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/falgy.2023.1201807
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2673-6101
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/11154
dc.language.isoeng
dc.publisherFrontiers in Allergyspa
dc.publisher.journalFrontiers in Allergyspa
dc.relation.ispartofseriesFrontiers in Allergy, 2673-6101, 4, 2023, 1-5spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/falgy.2023.1201807/full
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectReacciones adversasspa
dc.subjectSíndrome de quilomicronemia familiarspa
dc.subjectPancreatitisspa
dc.subjectTriglicéridosspa
dc.subjectUrticariaspa
dc.subjectVolanesorsenspa
dc.subject.keywordsAdverse reactionsspa
dc.subject.keywordsFamilial chylomicronemia syndromespa
dc.subject.keywordsPancreatitisspa
dc.subject.keywordsTriglyceridesspa
dc.subject.keywordsUrticariaspa
dc.subject.keywordsVolanesorsenspa
dc.titleCase report: desensitization of hypersensitivity against the antisense oligonucleotide volanesorsenspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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