Predictors of survival after head and neck squamous cell carcinoma in South America: the interchange study

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dc.contributor.authorAbrahão, Renata
dc.contributor.authorPerdomo Lara, Sandra Janneth
dc.contributor.authorRibeiro Pinto, Luis Felipe
dc.contributor.authorNascimento de Carvalho, Flávia
dc.contributor.authorDias, Fernando Luis
dc.contributor.authorVasconcelos de Podestá, José Roberto
dc.contributor.authorvon Zeidler, Sandra Ventorin
dc.contributor.authorde Abreu, Priscila Marinho
dc.contributor.authorVilensky, Marta V.
dc.contributor.authorGiglio, Raúl Eduardo
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorSiqueira Mineiro, Matinair
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.authorIkeda, Mauro K.
dc.contributor.authorCuello, Mauricio A.
dc.contributor.authorMunyo, Andres
dc.contributor.authorRodríguez Urrego, Paula Andrea
dc.contributor.authorHakim, José Antonio
dc.contributor.authorSuarez-Zamora, David A.
dc.contributor.authorCayol, Federico
dc.contributor.authorFigari, Marcelo Fernando
dc.contributor.authorOliver, Javier
dc.contributor.authorGaborieau, Valérie
dc.contributor.authorKeogh, Ruth H.
dc.contributor.authorBrennan, Paul J.
dc.contributor.authorCurado, Maria Paula
dc.contributor.orcidPerdomo Lara, Sandra Janneth [0000-0002-4429-3760]
dc.date.accessioned2020-07-09T20:58:03Z
dc.date.available2020-07-09T20:58:03Z
dc.date.issued2020
dc.description.abstractenglishPURPOSE Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://ascopubs.org/doi/full/10.1200/GO.20.00014
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2378-9506
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3397
dc.language.isoeng
dc.publisherAmerican Society of Clinical Oncologyspa
dc.publisher.journalJournal of global oncologyspa
dc.relation.ispartofseriesJournal of global oncology, 2378-9506, Vol. 6, 2020spa
dc.relation.urihttps://ascopubs.org/doi/full/10.1200/GO.20.00014
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.decsNeoplasias laríngeasspa
dc.subject.decsMortalidadspa
dc.subject.decsInformes de casosspa
dc.titlePredictors of survival after head and neck squamous cell carcinoma in South America: the interchange studyspa
dc.title.translatedPredictors of survival after head and neck squamous cell carcinoma in South America: the interchange studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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