Patrones morfológicos cardiotocográficos asociados con asfixia perinatal

dc.contributor.advisorFranco Ayala, Luis Carlos
dc.contributor.authorMozo Acevedo, Diana Alejandra
dc.contributor.orcid0000-0002-4558-0200
dc.date.accessioned2025-07-22T16:30:49Z
dc.date.available2025-07-22T16:30:49Z
dc.date.issued2025-06
dc.description.abstractLa asfixia perinatal (AP) es un evento que produce acidosis neonatal durante el periodo periparto, con una incidencia general en Colombia de 40 -45 casos por cada 1000 nacidos vivos incluyendo AP leve, moderada y severa (1). Para su predicción se utiliza la cardiotocografía (CTG) interpretada con base en la clasificación propuesta por el Colegio Americano de Ginecología y Obstetricia (ACOG), a pesar de reportar una baja capacidad predictiva de AP. Objetivo: Analizar los patrones morfológicos cardiotocográficos asociados a AP. Metodología: Estudio retrospectivo de casos y controles. Mujeres gestantes con edad gestacional mayor a 32 semanas a quienes se les realizó CTG en trabajo de parto durante el periodo comprendido entre 2018-2021. Resultados: Se incluyeron 410 pacientes en el estudio, 37 casos y 373 controles. En el análisis bivariado el estrato socioeconómico bajo, el parto instrumentado, la triple I y en la CTG la variabilidad mínima, la ausencia de aceleraciones, las desaceleraciones de respuesta lenta y la velocidad de tendencia al cambio se asociaron con mayor riesgo de AP. En el análisis multivariado, el estrato socioeconómico, el parto instrumentado, la reanimación in útero y la variabilidad mínima en la CTG se identificaron como factores de riesgo para AP. Conclusiones: Algunos patrones morfológicos cardiotográficos específicos podrían asociarse con AP y no hacen parte de las clasificaciones actuales de la CTG. Se requieren estudios de mayor potencia estadística y muestra con mayor frecuencia del evento para evaluar estas posibles asociaciones.
dc.description.abstractenglishPerinatal asphyxia (PA) is an event that leads to neonatal acidosis during the peripartum period, with an general incidence of 40-45 cases per 1000 live births in Colombia including mild, moderate, and severe PA (1). Cardiotocography (CTG) is used to predict PA, interpreted based on the classification proposed by the American College of Obstetricians and Gynecologists (ACOG), despite its reported low predictive capacity for PA. Objective: To analyze CTG morphological patterns associated with PA. Methods: A retrospective case-control study. Pregnant women with a gestational age greater than 32 weeks, who underwent CTG during labor between 2018-2021 were included. Results: A total of 410 patients were included in the study, 37 cases and 373 controls. In the bivariate analysis, low socioeconomic status, instrumental delivery, triple I, and CTG findings such as minimal variability, absence of accelerations, slow response decelerations, and trend change rate were associated with a higher risk of PA. In the multivariate analysis, socioeconomic status, assisted vaginal delivery, in-utero resuscitation, and minimal CTG variability were identified as risk factors for PA. Conclusions: Certain specific CTG morphological patterns may be associated with PA and are not currently included in existing CTG classifications. Further studies with larger sample sizes and greater event frequency are needed to establish these associations.
dc.description.degreelevelEspecializaciónspa
dc.description.degreenameEspecialista en Ginecología y Obstetriciaspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/15018
dc.language.isoes
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programEspecialización en Ginecología y Obstetriciaspa
dc.relation.referencesPiñeros J, Troncoso G, Serrano C, Espinosa E. Consenso De ExpertosDiagnóstico, Manejo, Monitoreo Y Seguimiento DelRecién Nacido Con Asfixia Perinatal, EncefalopatíaHipóxico Isquémica (Ehi), E Hipotermia Terapeutica (Ht). https://ascon.org.co/wp-content/uploads/2021/02/CONSENSO-NEUROLOGIA-Y-NEONATOLOGIA1.pdf [Internet]. 2021;1–51. Available from: https://ascon.org.co/wp-content/uploads/2021/02/CONSENSO-NEUROLOGIA-Y-NEONATOLOGIA1.pdf
dc.relation.referencesE Lawn , S. Cousens JZ. MDGs and newborn babies. Lancet [Internet]. 2005;365:891–900. Available from: http://www.measuredhs.com
dc.relation.referencesACOG. Practice Bulletin Clinical Management Guidelines for Obstetrician - Intrapartum Fetal Heart Rate Monitoring: Nomenclature, Interpretation, and General Management Principles. Obstet Gynecol [Internet]. 2009;114(106):192–202. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21422879
dc.relation.referencesThe American College of Obstetricians and Gynaecologists. Executive summary: Neonatal Encephalopathy and Neurologic Outcome, Second Edition. Obstet Gynecol. 2014;123(4):896–901.
dc.relation.referencesMoshiro R, Mdoe P, Perlman JM. A Global View of Neonatal Asphyxia and Resuscitation. 2019;7(November):1–6
dc.relation.referencesKurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev [Internet]. 2010;86(6):329–38. Available from: http://dx.doi.org/10.1016/j.earlhumdev.2010.05.010
dc.relation.referencesWeissbach T, Heusler I, Ovadia M, David L, Daykan Y, Schreiber F, et al. The temporal effect of Category II fetal monitoring on neonatal outcomes. Eur J Obstet Gynecol Reprod Biol [Internet]. 2018;229:8–14. Available from: https://doi.org/10.1016/j.ejogrb.2018.07.030
dc.relation.referencesSanto S, Ayres-de-Campos D, Costa-Santos C, Schnettler W, Ugwumadu A, Da Graça LM, et al. Agreement and accuracy using the FIGO, ACOG and NICE cardiotocography interpretation guidelines. Acta Obstet Gynecol Scand. 2017;96(2):166–75
dc.relation.referencesVintzileos AM, Mph JCS. variability : have we overlooked the significance of longitudinal fetal heart rate changes for detecting intrapartum fetal hypoxia ? Am J Obstet Gynecol [Internet]. 2016;215(3):261–4. Available from: http://dx.doi.org/10.1016/j.ajog.2016.05.046
dc.relation.referencesL. C. Franco Ayala, S. Buitrago, J. Machado, C. Trillos, M. P. Franco Pinzon, L. F. Pinto Rueda IA. EP20.33: Frequent cardiotocography morphologies in cases of perinatal asphyxia. Ultrasound Obstet Gynecol. 2023
dc.relation.referencesBogdanovic G, Babovic A, Rizvanovic M, Ljuca D. Cardiotocography in the Prognosis of Perinatal Outcome. 2014;68(2):102–5
dc.relation.referencesEvans MI, Britt DW, Eden RD, Gallagher P, Evans SM, Schifrin BS. The Fetal Reserve Index Significantly Outperforms ACOG Category System in Predicting Cord Blood Base Excess and pH : A Methodological Failure of the Category System. 2019
dc.relation.referencesBentancor, V. C. Bertoche, R. Pison, N. Martino CS. Análisis del diagnóstico de sospecha de hipoxia fetal en pacientes con indicación de cesárea por esta causa en el Centro Hospitalario. 2018;15–20.
dc.relation.referencesGraham EM, Adami RR, Mckenney SL, Burd I, Witter FR, Jennings JM. Diagnostic Accuracy of Fetal Heart Rate Monitoring in the Identification of Neonatal Encephalopathy. 2014;124(3):507–13
dc.relation.referencesUgwumadu A. Are we ( mis ) guided by current guidelines on intrapartum fetal heart rate monitoring ? Case for a more physiological approach to interpretation. 2014;1063–70
dc.relation.referencesCahill AG, Tuuli MG, Stout MJ, López JD, Macones GA. SC. Am J Obstet Gynecol [Internet]. 2018; Available from: https://doi.org/10.1016/j.ajog.2018.01.026
dc.relation.referencesFurukawa A, Neilson D, Hamilton E, Furukawa A, Neilson D, Cumulative EH. Cumulative deceleration area : a simplified predictor of metabolic acidemia. J Matern Neonatal Med [Internet]. 2019;0(0):1–8. Available from: https://doi.org/10.1080/14767058.2019.1678130
dc.relation.referencesIbarra-r D, Mota-reyes A. Pathophysiology of Perinatal Asphyxia in Humans and Animal Models. 2022
dc.relation.referencesRiesgo-prendes L, Salamanca-matta AL, Monterrey-gutiérrez PA, Bermúdez-hernández PA, Vélez JL. Hipoxia perinatal en el Hospital Mederi de Bogotá: comportamiento en los años 2007 a 2011. 2017;19(3):332–9
dc.relation.referencesSemanal BE. Unidades de análisis y tableros de problemas , semanas epidemiológicas 01 a la 24 de 2023. 2023
dc.relation.referencesBogotá FSF de. Informe de gestión sostenible. Fund St Fe Bogotá. 2021
dc.relation.referencesComunicaciones. Cifras historicas de nacimientos en el Instituto Materno Infantil. Subred Integr Serv Salud Cent Oriente ESE. 2020;(Cifras historicas de nacimientos en el Instituto Materno Infantil).
dc.relation.referencesGillam-Krakauer M GJC. Birth Asphyxia. StatPearls [Internet]. 2024
dc.relation.referencesTerré C FL. Monitorización biofísica intraparto. Matronas Prof. 2006;7(2):5–13
dc.relation.referencesFarquhar CM, Armstrong S, Masson V. Clinician Identification of Birth Asphyxia Using Intrapartum Cardiotocography Among Neonates With and Without Encephalopathy in New Zealand. 2020;3(2):1–11
dc.relation.referencesSholapurkar. Categorization of Fetal Heart Rate Decelerations in American and European Practice: Importance and Imperative of Avoiding Framing and Confirmation Biases. J Clin Med Res. 2015;7(9):672
dc.relation.referencesBarber EL, Lundsberg LS, Belanger K, Pettker CM, Funai EF, Illuzzi JL. Indications contributing to the increasing cesarean delivery rate. Obstet Gynecol. 2011;118(1):29–38
dc.relation.referencesCarbonne B, Pons K, Maisonneuve E. Foetal scalp blood sampling during labour for pH and lactate measurements. Best Pract Res Clin Obstet Gynaecol [Internet]. 2016;30(July):62–7. Available from: http://dx.doi.org/10.1016/j.bpobgyn.2015.05.006
dc.relation.referencesTsikouras P, Koukouli Z, Niesigk B, Manav B, Farmakides G, Csorba R, et al. Predictive value of fetal scalp pH and base excess for fetal acidosis and poor neonatal outcome. J Matern Neonatal Med. 2018;31(23):3166–71
dc.relation.referencesGarite TJ, Simpson KR. Intrauterine resuscitation during labor. Clin Obstet Gynecol. 2011;54(1):28–39.
dc.relation.referencesSimpson KR. Intrauterine Resuscitation During Labor: Review of Current Methods and Supportive Evidence. J Midwifery Women’s Heal. 2007;52(3):229–37
dc.relation.referencesBullens LM, Hulsenboom ADJ, Moors S, Joshi R, Van Runnard Heimel PJ, Van Der Hout-Van Der Jagt MB, et al. Correction to: Intrauterine resuscitation during the second stage of term labour by maternal hyperoxygenation versus conventional care: Study protocol for a randomised controlled trial (INTEREST O2) (Trials (2018) 19 (195) DOI: 10.1186/s13063-018-2567-x). Trials. 2018;19(1):1–11
dc.relation.referencesEsmail A, Bland M. Caesarean section for fetal distress. Lancet. 1990;336(8718):819
dc.relation.referencesRoy KK, Baruah J, Kumar S, Deorari AK, Sharma JB, Karmakar D. Cesarean section for suspected fetal distress, continuous fetal heart monitoring and decision to delivery time. Indian J Pediatr. 2008;75(12):1249–52
dc.relation.referencesGarabedian C, De Jonckheere J, Butruille L, Deruelle P, Storme L, Houfflin-Debarge V. Understanding fetal physiology and second line monitoring during labor. J Gynecol Obstet Hum Reprod [Internet]. 2017;46(2):113–7. Available from: http://dx.doi.org/10.1016/j.jogoh.2016.11.005
dc.relation.referencesGrivell RM, Alfirevic Z, Gyte GML, Devane D. Antenatal cardiotocography for fetal assessment. Cochrane Database Syst Rev. 2015;2015(9):1–39
dc.relation.referencesSalcedo-Ramos Francisco, Méndez-Rodríguez Rogelio, Vallejo-Navarro Carolina. Fetal Monitoring During the Obstetric Labor. 2015;170–8
dc.relation.referencesJia YJ, Chen X, Cui HY, Whelehan V, Archer A, Chandraharan E. Physiological CTG interpretation: the significance of baseline fetal heart rate changes after the onset of decelerations and associated perinatal outcomes. J Matern Neonatal Med [Internet]. 2021;34(14):2349–54. Available from: https://doi.org/10.1080/14767058.2019.1666819
dc.relation.referencesDoret M, Constans A, Gaucherand P. Bases physiologiques de l’analyse du rythme cardiaque fœtal au cours du travail. J Gynecol Obstet Biol la Reprod [Internet]. 2010;39(4):276–83. Available from: http://dx.doi.org/10.1016/j.jgyn.2010.01.004
dc.relation.referencesCastelazo-ayala L. Un tributo a Roberto Caldeyro-Barcia, considerado el pionero de la Perinatología. 2017;31(1):39–43
dc.relation.referencesEden RD, Evans MI, Britt DW, Evans SM, Schifrin BS. Safely lowering the emergency Cesarean and operative vaginal delivery rates using the Fetal Reserve Index. J Matern Neonatal Med [Internet]. 2020;33(9):1473–9. Available from: https://doi.org/10.1080/14767058.2018.1519799
dc.relation.referencesGamboa SM, Moros ML, Mancho JP, Moros CL, Mateo SC. Deceleration area and fetal acidemia. J Matern Neonatal Med [Internet]. 2017;30(21):2578–84. Available from: http://dx.doi.org/10.1080/14767058.2016.1256993
dc.relation.referencesFranco LC, Buitrago SM, Arbelaez I, Pinto LF, Blanco D, Pizarro MC, et al. Development, Validation, and Diagnostic Accuracy of the Fetal Lack of Responsiveness Scale for Diagnosis of Severe Perinatal Hypoxia. J Pregnancy. 2024;2024:9779831
dc.relation.referencesRAM KMS. Sample size for unmatched case-control studies. cited 2024 Feb 29
dc.relation.referencesRojas Cardenas C, Sánchez León EM. FACTORES ASOCIADOS A MORTALIDAD NEONATAL EN PACIENTES CON DIAGNÓSTICO DE ASFIXIA PERINATAL. Repos Univ el Bosque. 2014;48.
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Internationalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCardiotocografía
dc.subjectMonitoria fetal
dc.subjectAsfixia perinatal
dc.subject.keywordsCardiotocography
dc.subject.keywordsPerinatal asphyxia
dc.subject.keywordsFetal monitoring
dc.subject.nlmWP 100
dc.titlePatrones morfológicos cardiotocográficos asociados con asfixia perinatal
dc.title.translatedCardiotocographic morphological patterns associated with perinatal asphyxia
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Especializaciónspa

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