Revisión narrativa de hojas de coca como tratamiento alternativo para el mal agudo de montaña

Vista sencilla de ítem
dc.contributor.advisorDe Jesus Pianeta, Oscar
dc.contributor.authorQuintero Gutierrez, Andres Camilo
dc.contributor.orcidQUINTERO , ANDRES 0009-0008-7410-0780
dc.date.accessioned2025-05-02T14:07:24Z
dc.date.available2025-05-02T14:07:24Z
dc.date.issued2025-04
dc.description.abstractLa enfermedad desadaptativa llamada Mal Agudo de Montaña afecta a muchos viajeros, montañeros y guías en entornos de altura. Muchos buscan respuestas en la medicina alopática para aliviar esta dolencia mientras viajan. Tradicionalmente, los indígenas de Sudamérica tenían la respuesta en las hojas de coca, una planta infame en la cual, por tradición oral, se ha heredado el antiguo arte del mambeo. El propósito de este artículo es revisar artículos internacionales previos respecto al mecanismo de los metabolitos de la hoja de coca y su correlación con el Mal Agudo de Montaña (MAM), y postular la viabilidad de la hoja de coca para ser considerada como una alternativa de tratamiento para esta enfermedad.
dc.description.abstractenglishBackground: Acute Mountain Sickness (AMS) poses a significant health concern for individuals traversing high-altitude environments, prompting varied approaches to its mitigation. Purpose: This narrative review delves into the indigenous use of coca leaves by South American populations as a traditional remedy for AMS, juxtaposing it against contemporary allopathic treatments. Study design: International research on the metabolites of coca leaves and their potential correlation with AMS is synthesized, with a focus on understanding the biochemical intricacies of the plant. Methods: A comprehensive review of literature spanning both traditional indigenous knowledge and modern scientific studies is conducted to explore the therapeutic potential of coca leaves in managing AMS. Results: The examination reveals promising connections between the metabolites present in coca leaves and potential alleviation of AMS symptoms, shedding light on its alternative treatment viability. Conclusion: Coca leaves emerge as a potentially effective alternative treatment for AMS, warranting further investigation and consideration in the context of high-altitude travel and mountaineering.
dc.description.degreelevelPregradospa
dc.description.degreenameMédico Cirujanospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/14279
dc.language.isoes
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programMedicinaspa
dc.relation.references1. Alke, V. (2023,27 julio) . Coca Talks. [¿Que sabemos sobre la coca desde la ciencia?], Futuro coca , Bogota, Colombia. https://www.youtube.com/watch?v=8f9VcjU5vIU&t=478s&ab_channel=CesedUn iandes
dc.relation.references2.
dc.relation.references3. Asociación Civil de Investigación y Desarrollo en Salud. (2017). Guía para el alumno: Primeros Socorros Estándares en lugares remotos. Alliance for World Wide Editing. www.aider.org
dc.relation.references4. Auerbach, P. S., Cushing, T. A., & Harris, N. S. (2016). Auerbach’s wilderness Medicine. Saunders.
dc.relation.references5. Bigham, A. W., & Lee, F. S. (2014). Human high-altitude adaptation: forward genetics meets the HIF pathway. Genes & development, 28(20), 2189–2204. https://doi.org/10.1101/gad.250167.114
dc.relation.references6. Biondich, A. S., & Joslin, J. (2015). Coca: High Altitude Remedy of the Ancient Incas. Wilderness & Environmental Medicine, 26(4), 567-571. https://doi.org/10.1016/j.wem.2015.07.006
dc.relation.references7. Biondich, A. S., & Joslin, J. (2016). Coca: the history and medical significance of an ancient Andean tradition. Emergency Medicine International, 2016, 1-5. https://doi.org/10.1155/2016/4048764
dc.relation.references8.
dc.relation.references9. Caravedo, M. A., Mozo, K., Morales, M., Smiley, H., Stuart, J., Tilley, D. H., & Cabada, M. M. (2021). Risk factors for acute mountain sickness in travellers to Cusco, Peru: coca leaves, obesity and sex. Journal of Travel Medicine, 29(5). https://doi.org/10.1093/jtm/taab102
dc.relation.references10. Casale, J. F., Mallette, J. R., & Jones, L. M. (2014). Chemosystematic identification of fifteen new cocaine-bearing erythroxylum cultigens grown in Colombia for illicit cocaine production. Forensic Science International, 237, 30-39. https://doi.org/10.1016/j.forsciint.2014.01.012
dc.relation.references11. Casikar, V., Mujica, E., Mongelli, M., Aliaga, J. M. R., López, N. T., Smith, C. N., & Bartholomew, F. (2010). Does chewing coca leaves influence physiology at high altitude? Indian Journal of Clinical Biochemistry, 25(3), 311-314. https://doi.org/10.1007/s12291-010-0059-1
dc.relation.references12. Conway, R., Evans, I. S., & Weeraman, D. (2012). Assessing travelers’ knowledge and use of Coca for altitude sickness. Wilderness & Environmental Medicine, 23(4), 373-374. https://doi.org/10.1016/j.wem.2012.06.005
dc.relation.references13. Cruz, J. C., Díaz, C. J., Marticorena, E., & Hilario, V. (1979). Phlebotomy improves pulmonary gas exchange in chronic mountain polycythemia. Respiration, 38(6), 305-313. https://doi.org/10.1159/000194097
dc.relation.references14. Davis, C., & Hackett, P. H. (2017). Advances in the prevention and treatment of high altitude illness. Emergency Medicine Clinics of North America, 35(2), 241-260. https://doi.org/10.1016/j.emc.2017.01.002
dc.relation.references15. Diniz, T. C., Silva, J. C., De Lima-Saraiva, S. R. G., De Almeida Ribeiro, F. P. R., Pacheco, A. G. M., De Freitas, R. M., Quintans‐Júnior, L. J., De Souza Siqueira Quintans, J., Mendes, R. L., & Da Silva Almeida, J. R. G. (2015). The role of flavonoids on oxidative stress in epilepsy. Oxidative Medicine and Cellular Longevity, 2015, 1-9. https://doi.org/10.1155/2015/171756
dc.relation.references16. Dominguez, Y. C. C., Hoyos-Garcés, G., Yépez, R., & Sandoval-Pinedo, D. K. (2021). Usos agroindustriales de la hoja de coca en comunidades indígenas del departamento del Cauca, Colombia durante el postconflicto. Política, globalidad y ciudadanía. https://doi.org/10.29105/pgc7.14-3
dc.relation.references17. Fattinger, K., Benowitz, N. L., Jones, R. T., & Verotta, D. (2000). Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine. European Journal of Clinical Pharmacology, https://doi.org/10.1007/s002280000147
dc.relation.references18. Fuchs, A., Burchard, R. E., Curtain, C. C., De Azeredo, P. R., Frisancho, A. R., Gagliano, J. A., Katz, S. H., Little, M. A., Mazess, R. B., Picón-Reátegui, E., Sever, L. E., Tyagi, D. V. S., & Wood, C. S. (1978). Coca Chewing and High-Altitude Stress: Possible effects of coca alkaloids on erythropoiesis [and comments and reply]. https://doi.org/10.1086/202075
dc.relation.references19. Gamarra, V., Fuertes R, C., Chavez S, N., Contreras C, D., Goya S, E., Huamantumba B, K., Retuerto P, F., & Ruiz Pacco, G. (2018). Metabolitos en las hojas de Erythroxylum coca Lam y Erithroxylum novogranatense (Morris) Vieron y evaluacion de sus propiedades biologicas mediante bioensayos. Revista peruana de medicina integrativa, 2(4), 828–834. https://doi.org/10.26722/rpmi.2017.24.70
dc.relation.references20. Goris, S. J. A. G. (2015). Utilidad y tipos de revisión de literatura. Ene, 9(2), 0. https://doi.org/10.4321/s1988-348x2015000200002
dc.relation.references21. Guðbjartsson, T., Sigurðsson, E., Gottfreðsson, M., Björnsson, Ó. M., & Guðmundsson, G. (2019). Hæðarveiki og tengdir sjúkdómar. Laeknabladid, 2019(11), 499-507. https://doi.org/10.17992/lbl.2019.11.257
dc.relation.references22. Hartman-Ksycińska, A., Kluz-Zawadzka, J., & Lewandowski, B. (2016). High altitude illness. ResearchGate. https://www.researchgate.net/publication/311049813_High_altitude_illness
dc.relation.references23. Hasan, A. (2009). Handbook of Blood Gas/Acid–Base Interpretation. En Springer eBooks. https://doi.org/10.1007/978-1-84800-334-7
dc.relation.references24. Hoffman, R. S., Smilkstein, M. J., & Goldfrank, L. R. (1990). Whole bowel irrigation and the cocaine body-packer: a new approach to a common problem. American Journal of Emergency https://doi.org/10.1016/0735-6757(90)90155-s
dc.relation.references25. Hubert, G. W., Jones, D. C., Moffett, M. C., Rogge, G. A., & Kuhar, M. J. (2008). CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system. Biochemical Pharmacology, 75(1), 57-62. https://doi.org/10.1016/j.bcp.2007.07.028
dc.relation.references26. Jenkins, A. J., Llosa, T., Montoya, I. D., & Cone, E. J. (1996). Identification and quantitation of alkaloids in coca tea. Forensic Science International, 77(3), 179-189. https://doi.org/10.1016/0379-0738(95)01860-3
dc.relation.references27. Jensen, J. D. (2023). High altitude pulmonary edema. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK430819/
dc.relation.references28. Jiao, W., Wang, Y., Kong, L., Ouyang, T., Meng, Q., Fu, Q., & Hu, Z. (2018). CART peptide activates the NRF2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer’s disease. Biochemical and Biophysical Research Communications, https://doi.org/10.1016/j.bbrc.2018.05.101
dc.relation.references29. Johnson, E. L., Schmidt, W. F., & Cooper, D. A. (2002). Flavonoids as chemotaxonomic markers for cultivated amazonian coca. Plant Physiology and Biochemistry, 40(1), 89-95. https://doi.org/10.1016/s0981-9428(01)01348-1
dc.relation.references30. Jonczyk, A., Kafara, Z., Baranowska, W., & Jurczak, D. (2023). Prevention of acute mountain sickness (AMS) with particular emphasis on hydration: a review. Journal of Kinesiology and Exercise Sciences, 33(102), 1-15. https://doi.org/10.5604/01.3001.0053.8651
dc.relation.references31. Jones, W., & Kinghorn, A. D. (2012). Extraction of plant secondary metabolites. En Methods in molecular https://doi.org/10.1007/978-1-61779-624-1_13 biology (pp. 341-366).
dc.relation.references32. Khan, K. M., Patel, J. B., & Schaefer, T. J. (2023). Nifedipine. https://pubmed.ncbi.nlm.nih.gov/30725737/
dc.relation.references33. Kim, S. T., & Park, T. (2019). Acute and chronic effects of cocaine on cardiovascular health. International Journal of Molecular Sciences, 20(3), 584. https://doi.org/10.3390/ijms20030584
dc.relation.references34. León‐Velarde, F., Maggiorini, M., Reeves, J. Τ., Aldashev, A., Asmus, I., Bernardi, L., Ge, R. L., Hackett, P. H., Kobayashi, T., Moore, L. G., Peñaloza, D., Richalet, J., Roach, R. C., Wu, T., Vargas, E., Zubieta-Castillo, G., & Zubieta-Calleja, G. (2005). Consensus Statement on Chronic and Subacute High Altitude Diseases. High Altitude Medicine & Biology, 6(2), 47 147-157. https://doi.org/10.1089/ham.2005.6.147
dc.relation.references35. Levine, B. D., Yoshimura, K., Kobayashi, T., Fukushima, M., Shibamoto, T., & Ueda, G. (1989). Dexamethasone in the Treatment of Acute Mountain Sickness. The New England Journal of Medicine, 321(25), 1707-1713. https://doi.org/10.1056/nejm198912213212504
dc.relation.references36. Luks, A. M., McIntosh, S., Grissom, C. K., Auerbach, P. S., Rodway, G. W., Schoene, R. B., Zafren, K., & Hackett, P. H. (2014). Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2014 Update. Wilderness & Environmental Medicine, 25(4), S4-S14. https://doi.org/10.1016/j.wem.2014.06.017
dc.relation.references37. Mao, P., Meshul, C. K., Thuillier, P., Goldberg, N. R., & Reddy, P. H. (2012). CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria. PLOS ONE, https://doi.org/10.1371/journal.pone.0029343
dc.relation.references38. Mario, G. G. (1997). Efectos del acullico de coca en la prueba de tolerancia a la glucosa. Medicina (B.Aires);57(3): 261-4, 1997. graf https://pesquisa.bvsalud.org/portal/resource/pt/lil-209638
dc.relation.references39. Moore, L. G. (2001). Human genetic adaptation to high altitude. High Altitude Medicine & Biology, 2(2), 257-279. https://doi.org/10.1089/152702901750265341
dc.relation.references40. Okumiya, K., Sakamoto, R., Kimura, Y., Ishimoto, Y., Wada, T., Ishine, M., Ishikawa, M., Nakajima, S., Hozo, R., Ge, R., Norboo, T., Otsuka, K., & Matsubayashi, K. (2010). Strong Association Between Polycythemia and Glucose Intolerance in Elderly High‐Altitude Dwellers in Asia. Journal of the American Geriatrics Society, https://doi.org/10.1111/j.1532-5415.2010.02753.x 58(3), 609-611.
dc.relation.references41. Paralikar, S., & Paralikar, J. H. (2010). High-altitude medicine. Indian Journal of Occupational and Environmental https://doi.org/10.4103/0019-5278.64608
dc.relation.references42. Patiño, J. F., Restrepo, J. F. P., & Rodríguez, E. C. (2015). Gases sanguíneos, fisiología de la respiración e insuficiencia respiratoria aguda. Ed. Médica Panamericana.
dc.relation.references43. Patir, H., Sarada, S., Singh, S., Mathew, T. L., Singh, B., & Bansal, A. (2012). Quercetin as a prophylactic measure against high altitude cerebral edema. Free Radical Biology and Medicine, https://doi.org/10.1016/j.freeradbiomed.2012.06.010
dc.relation.references44. Patková, A., Joskova, V., Havel, E., Kovařík, M., Kuchařová, M., Zadák, Z., & Hronek, M. (2017). Energy, protein, carbohydrate, and lipid intakes and their effects on morbidity and mortality in critically ill adult patients: a systematic review. Advances in https://doi.org/10.3945/an.117.015172
dc.relation.references45. Piñacue, J. (2023). Coca Talks. [Futuro coca: cuales son los retos y oportunidades hacia ¿a futuro para las comunidades indígenas que usan la coca de manera ancestral?], Futuro coca, Bogotá, Colombia
dc.relation.references46. Pramanik, P., & Vidua, R. K. (2016). Sudden Cardiac Death of a Body Packer Due to Cocaine Cardiotoxicity. Clinical Medicine Insights: Pathology, 9, CPath.S41070. https://doi.org/10.4137/cpath.s41070
dc.relation.references47. Restrepo, D. A., Saenz, E., Jara-Muñoz, O. A., Calixto-Botía, I., Rodríguez-Suárez, S., Zuleta, P., Chavez, B. G., Sánchez, J. A., & D’Auria, J. C. (2019). Erythroxylum in Focus: An interdisciplinary review of an overlooked genus. Molecules, 24(20), 3788. https://doi.org/10.3390/molecules24203788
dc.relation.references48. Richalet, J., Rivera, M. C., Bouchet, P., Chirinos, E., Onnen, I., Petitjean, O., Bienvenu, A., Lasne, F., Moutereau, S., & León‐Velarde, F. (2005). Acetazolamide. American Journal of Respiratory and Critical Care Medicine, 172(11), 1427-1433. https://doi.org/10.1164/rccm.200505-807oc
dc.relation.references49. Ricardo, A., Miguez, H., Peñaloza, R., Torres, G., Vera, O., Velarde, J., Huarachi, N., Mamani, R., & Cuevas, H. (2013). Eritrocitosis Patológica de Altura: Caracterización Biológica, Diagnóstico y Tratamiento. Revista médica - Colegio Médico de La Paz, 19(2), 5–18. http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1726-895820130002 00002
dc.relation.references50. Roach, R. C., Hackett, P. H., Oelz, O., Bärtsch, P., Luks, A. M., MacInnis, M. J., & Baillie, J. K. (2018). The 2018 Lake Louise Acute Mountain Sickness score. High Altitude Medicine & Biology, 19(1), 4-6. https://doi.org/10.1089/ham.2017.0164
dc.relation.references51. Salinas-Piélago, J. E. (2016). Revisión sobre el uso del mate de hoja de coca en la prevención del mal agudo de montaña. Revista de neuro-psiquiatría, 79(3), 166. https://doi.org/10.20453/rnp.v79i3.2922
dc.relation.references52. Savioli, G., Ceresa, I. F., Gori, G., Fumoso, F., Gri, N., Floris, V., Varesi, A., Martuscelli, E., Marchisio, S., Longhitano, Y., Ricevuti, G., Esposito, C., Caironi, G., Giardini, G., & Zanza, C. (2022). Pathophysiology and Therapy of High-Altitude Sickness: Practical approach in emergency and Critical care. Journal of Clinical Medicine, 11(14), 3937. https://doi.org/10.3390/jcm11143937
dc.relation.references53. Scheidweiler, K. B., Spargo, E. A. K., Kelly, T., Cone, E. J., Barnes, A. J., & Huestis, M. A. (2010). Pharmacokinetics of cocaine and metabolites in human oral fluid and correlation with plasma concentrations after controlled administration. Therapeutic Drug Monitoring, https://doi.org/10.1097/ftd.0b013e3181f2b729
dc.relation.references54. Schmickl, C. N., Owens, R. L., Orr, J. E., Edwards, B. A., & Malhotra, A. (2020). Side effects of acetazolamide: A systematic review and meta-analysis assessing overall risk and dose dependence. BMJ Open Respiratory Research, 7(1), e000557. https://doi.org/10.1136/bmjresp-2020-000557
dc.relation.references55. Sinex, J. A., & Chapman, R. F. (2015). Hypoxic training methods for improving endurance exercise performance. Journal of Sport and Health Science, 4(4), 325-332. https://doi.org/10.1016/j.jshs.2015.07.005
dc.relation.references56. Stahl, S. M., Pradko, J. F., Haight, B. R., Modell, J. G., Rockett, C. B., & Learned-Coughlin, S. (2004). A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor. The primary care companion for CNS disorders, 6(4). https://doi.org/10.4088/pcc.v06n0403
dc.relation.references57. Stüber, T., Sartori, C., Schwab, M., Jayet, P., Rimoldi, S. F., Garcin, S., Thalmann, S., Spielvogel, H., Salmón, C. S., Villena, M., Scherrer, U., & Allemann, Y. (2010). Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness. Chest, 137(2), 388-392. https://doi.org/10.1378/chest.09-1355
dc.relation.references58. Tiwari, A., Moghal, M., & Meleagros, L. (2006). Life threatening abdominal complications following cocaine abuse. Journal of the Royal Society of Medicine, 99(2), 51-52. https://doi.org/10.1177/014107680609900203
dc.relation.references59. Vardy, J., Chiew, K. S., Galica, J., Pond, G. R., & Tannock, I. F. (2006). Side effects associated with the use of dexamethasone for prophylaxis of delayed emesis after moderately emetogenic chemotherapy. British Journal of Cancer, 94(7), 1011-1015. https://doi.org/10.1038/sj.bjc.6603048
dc.relation.references60. Venturino, M. (2006). Lake Louise Score (LLS) for the diagnosis of Acute Mountain Sickness
dc.relation.references61. Villafuerte, F. C., & Corante, N. (2016). Chronic mountain sickness: clinical aspects, etiology, management, and treatment. High Altitude Medicine & Biology, 17(2), 61-69. https://doi.org/10.1089/ham.2016.0031
dc.relation.references62. Wang, H., Liu, W., Yang, D., & Liu, J. (2012). [The acclimatization to extreme environments and its physiological mechanisms]. ResearchGate. https://www.researchgate.net/publication/236197608_The_acclimatization_to_extr eme_environments_and_its_physiological_mechanisms
dc.relation.references63. Zuleta, P., & Daza, D. L. (2018). El mambeo de la hoja de coca como una forma nutricional. https://elementaddhh.org/
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCoca
dc.subjectAMS
dc.subjectAltura
dc.subject.keywordsCoca leaf
dc.subject.keywordsAMS
dc.subject.keywordsMountain
dc.subject.nlmW100
dc.titleRevisión narrativa de hojas de coca como tratamiento alternativo para el mal agudo de montaña
dc.title.translatedNarrative review of coca leafs as acute mountain sickness treatment
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Pregradospa

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Trabajo de grado.pdf
Tamaño:
2.31 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 3 de 3
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.95 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
No hay miniatura disponible
Nombre:
Carta de autorizacion.pdf
Tamaño:
358.33 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
No hay miniatura disponible
Nombre:
Anexo 1 acta de aprobacion.pdf
Tamaño:
141.05 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar

Colecciones

Medicina