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    Studying neurotrophin antiviral effect on rabies-infected dorsal root ganglia cultures

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    TY - GEN T1 - Studying neurotrophin antiviral effect on rabies-infected dorsal root ganglia cultures UR - http://hdl.handle.net/20.500.12495/5420 PB - Springer Nature AB - ER - @misc{20.500.12495_5420, author = {}, title = {Studying neurotrophin antiviral effect on rabies-infected dorsal root ganglia cultures}, year = {}, abstract = {}, url = {http://hdl.handle.net/20.500.12495/5420} }RT Generic T1 Studying neurotrophin antiviral effect on rabies-infected dorsal root ganglia cultures LK http://hdl.handle.net/20.500.12495/5420 PB Springer Nature AB OL Spanish (121)
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    Author
    Castellanos, Jaime
    Martínez-Gutiérrez, Marlén
    Hurtado, Hernán
    Kassis, Raïd
    Bourhy, Hervé
    Acosta, Orlando
    Lafon, Monique
    Date
    2005-07
    Published in
    Journal of neuroVirology, 1538-2443, Vol. 11, Nor. 4, 2005, p. 403-410
    Published for
    Springer Nature
    URI
    http://hdl.handle.net/20.500.12495/5420
    Source's URL
    https://link.springer.com/article/10.1080/13550280500187252
    DOI
    https://doi.org/10.1080/13550280500187252

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    Abstract
    Neurotrophin (NT)-induced modulation of rabies virus adsorption, transcription, and replication were analyzed in adult mouse dorsal root ganglia cultures. Different types of nerve growth factor and NT-3 treatment were tested before infection (pretreatment), during infection (transtreatment) and after withdrawing the viral inoculum (post-treatment). NT pretreatment for 4 days prior to infection produced a significant increase in the quantity of virus adsorbed into cultures and a concomitant increase in genomic viral RNA as measured by real time polymerase chain reaction (PCR). NT pretreatment triggered increased expression of two rabies virus receptors (NCAM and p75NTR); however, no increase in rabies virus transcription and expression could be observed. By contrast, NT treatment during and after infection (trans- and post-treatment) induced a strong decrease in the quantity of viral nucleoprotein genomic and messenger nucleoprotein RNAs. These findings suggested that NT had an intrinsic inhibitory effect on rabies virus infection, which was not counterbalanced by NTs’ rabies virus receptor—enhancing property and viral uptake. Adult mouse dorsal root ganglion cultures can be regarded as being a useful model for detecting therapeutic targets and evaluating experimental antiviral drugs.
    Keywords
    Antiviral effect
    Neurotrophins
    Rabies
    Real time PCR
    Sensory neuron
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