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dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorGómez Gutiérrez, Alberto
dc.contributor.authorDuarte, Yurani
dc.contributor.authorAmazo, Constanza
dc.contributor.authorManosalva, Clara
dc.contributor.authorChila M, Lorena
dc.contributor.authorCasas-Gómez, María Consuelo
dc.contributor.authorBriceño Balcázar, Ignacio
dc.date.accessioned2020-08-12T21:06:02Z
dc.date.available2020-08-12T21:06:02Z
dc.identifier.issn0034-9887spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/3774
dc.description.abstractBackground: Oxygen transport is altered in hemoglobinopathies. Aim: To study the distribution of hemoglobinopathies in Andean subjects without African ancestry. Material and Methods: We analyzed blood samples of 1,407 subjects aged 18 to 59 years (58% females), living in the central Andean region of Colombia, referred to discard hemoglobinopathies. The frequency and type of hemoglobinopathy was established by capillary and agarose gel electrophoresis. Results: The frequency of hemoglobinopathies was 34.5% and higher among females. The structural variants found were: AS-heterozygous hemoglobin (8.1%), homozygous SS (3.7%), heterozygous SC (2.2%), AC heterozygotes (0.5%) and heterozygous AE (0.3%). Quantitative variants found were Hb A-Beta thalassemia (13.91%) and Hb H (0.06%), Beta-thalassemia heterozygotes C (0.88%), S-Beta thalassemia heterozygotes (6.07%) and compound heterozygous SC/Beta thalassemia (0.25%), with a persistence of fetal hemoglobin 0. Composite thalassemia was also found in 31%. All techniques showed good correlation and capillary electrophoresis demonstrated a greater detection of hemoglobin variants. Conclusions: The frequency of hemoglobin variants in the analyzed population was high, which is an important public health indicator. The most common hemoglobin variant was HbA/Increased structural Hb A2 and the mos frequent structural hemoglobinopathy was sickle cell trait. Capillary electrophoresis can discern any Hb variants present in the population.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.language.isoengspa
dc.publisherSociedad Médica de Santiagospa
dc.relation.ispartofseriesRevista Médica de Chile, 0034-9887, Vol. 143, 2015, p. 1260-1268spa
dc.relation.urihttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872015001000004&lng=en&tlng=en#?spa
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleVariantes de hemoglobina en una población con impresión diagnóstica positiva para hemoglobinopatías en Colombiaspa
dc.type.localArtículo de revista
dc.subject.keywordsHematologic diseasesspa
dc.subject.keywordsHemoglobinopathiesspa
dc.subject.keywordsElectrophoresisspa
dc.subject.keywordsAgarose gelspa
dc.subject.keywordsSickle cell traitspa
dc.identifier.doihttp://dx.doi.org/10.4067/S0034-98872015001000004spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalRevista Médica de Chilespa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.identifier.instnameinstname:Universidad El Bosque
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.title.translatedHemoglobin variants in Colombian patients referred to discard hemoglobinopathiesspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abiertospa
dc.date.issued2015-10


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International