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dc.contributor.authorMoreno, Elizabeth
dc.contributor.authorGarcía, Sara Diana
dc.contributor.authorBainto, Emelia V.
dc.contributor.authorSalgado, Andrea P.
dc.contributor.authorParish, Austin
dc.contributor.authorRosellini, Benjamin D.
dc.contributor.authorUlloa-Gutierrez, Rolando
dc.contributor.authorGarrido, Luis Martin
dc.contributor.authorDueńas, Lourdes
dc.contributor.authorEstripeaut, Dora
dc.contributor.authorLuciani, Kathia
dc.contributor.authorRodríguez-Quiroz, Francisco J.
dc.contributor.authorDel Aguila, Olguita
dc.contributor.authorCamacho Moreno, German
dc.contributor.authorGómez Alba, Virgen
dc.contributor.authorViviani, Tamara
dc.contributor.authorÁlvarez-Olmos, Martha I
dc.contributor.authorde Souza Marques, Heloisa Helena
dc.contributor.authorFaugier-Fuentes, Enrique
dc.contributor.authorSaltigeral-Simental, Patricia
dc.contributor.authorLópez Medina, Eduardo
dc.contributor.authorMiño-León, Greta
dc.contributor.authorBeltrán, Sandra
dc.contributor.authorMartínez-Arellano, Lucila
dc.contributor.authorPírez, María Catalina
dc.contributor.authorCofré, Fernanda
dc.contributor.authorTremoulet, Adriana H.
dc.contributor.authorREKAMLATINA-2 Study Group Investigators
dc.description.abstractObjective: To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants <6 months of age as compared to those ≥6 months in Latin America. Methods: We evaluated 36 infants <6 months old and 940 infants ≥6 months old diagnosed with KD in Latin America. We compared differences in laboratory data, clinical presentation, treatment response, and coronary artery outcomes between the two cohorts. Results: The majority (78.1%) of infants and children ≥6 months of age were initially diagnosed with KD, as compared to only 38.2% of infants <6 months. Clinical features of KD were more commonly observed in the older cohort: oral changes (92 vs. 75%, P = 0.0023), extremity changes (74.6 vs. 57.1%, P = 0.029), and cervical lymphadenopathy (67.6 vs. 37.1%, P = 0.0004). Whether treated in the first 10 days of illness or after the 10th day, infants <6 months were at greater risk of developing a coronary artery aneurysm compared to KD patients ≥6 months treated at the same point in the course of illness [ ≤ 10 days (53.8 vs. 9.4%, P = 0.00012); >10 days (50 vs. 7.4%, P = 0.043)]. Conclusion: Our data show that despite treatment in the first 10 days of illness, infants <6 months of age in Latin America have a higher risk of developing a coronary artery aneurysm. Delay in the diagnosis leads to larger coronary artery aneurysms disproportionately in these infants. Thus, suspicion for KD should be high in this vulnerable
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in pediatrics. 2296-2360, Vol. 8, 2020spa
dc.rightsAttribution 4.0 International*
dc.titlePresentation and outcomes of Kawasaki disease in Latin American infants younger than 6 months of age: a multinational multicenter study of the REKAMLATINA networkspa
dc.type.localArtículo de revista
dc.subject.keywordsCoronary artery abnormalitiesspa
dc.subject.keywordsDelayed diagnosisspa
dc.subject.keywordsKawasaki diseasespa
dc.publisher.journalFrontiers in pediatricsspa
dc.identifier.instnameinstname:Universidad El Bosque
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosque
dc.title.translatedPresentation and outcomes of Kawasaki disease in Latin American infants younger than 6 months of age: a multinational multicenter study of the REKAMLATINA networkspa
dc.rights.accessrightsAcceso abiertospa

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Attribution 4.0 International
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