Papel de la enfermedad periodontal en el desarrollo de entidades inflamatorias de etiología autoinmune: implicaciones clínicas y desafíos terapéuticos
Munévar, Juan Carlos
Valle-Oñate, Rafael Raúl
Revista colombiana de reumatologia, 2027-9000, Vol. 19, Nro. 2, 2012, p. 84-91
Asociacion Colombiana de Reumatologia
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During the last decade the knowledge related to the pathogenesis of odontogenic infections and their possible association with systemic diseases has been of great interest. Periodontal pathogens that enter to bloodstream are involved in systemic pathological effects. The Focal Infection Theory is based on the pathophysiology correlation between chronic periodontitis and the development of certain autoimmune diseases. Rheumatoid arthritis as inflammatory disease is characterized by persistent synovitis and destruction of cartilage and bone. The etiology is uncertain, but some microorganisms may play important role in the lack of self- tolerance and the consequent development of autoimmunity. P. gingivalis may be involved in amplifying the immune response and induction of the disease in individuals with genetic susceptibility. Therefore, the concept of periodontal medicine as a discipline to integrate these associations has emerged.
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