Prevalencia del compromiso renal durante el primer año de seguimiento en pacientes con púrpura de Henoch Schönlein en una institución pediátrica de Bogotá, Colombia
Pérez López, Pilar
Mosquera Ponguta, Catalina
Malagón Gutiérrez, Clara
Revista Colombiana de Reumatología, 2027-9000, Vol. 24, Nro. 2, 2017, p. 63-69
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Introduction Henoch-Schönlein Purpura is the most common vasculitis in children, with kidney involvement remaining the main cause of morbidity and mortality. The spectrum of kidney involvement ranges from mild symptoms to the development of a nephrotic and/or nephritic syndrome or kidney failure. Objective To determine the clinic features at onset, and kidney involvement of patients with a final diagnosis of Henoch-Schönlein Purpura during the first month, 3 months, and up to the first year of follow-up. Methods A retrospective study conducted on patients with a final diagnosis of Henoch-Schönlein Purpura in a Paediatric Rheumatology Department in an institution of Bogota, Colombia, during the period between 2010 and 2016. Results The study included 86 patients, 42 girls and 44 boys. The median age at disease onset was 5.3 years (SD 2.4 years: range 1 - 14 years). Kidney involvement was present in 39/86 (45%) patients. A trend to kidney involvement was observed in patients with abdominal symptoms (p=,053). The most frequent clinical finding was isolated proteinuria (49%), followed of proteinuria/haematuria (28%), and isolated hematuria (15%). Renal biopsy was performed on 8/39 patients with Henoch-Schönlein Purpura nephritis. The mean follow-up was 26.8 months (SD 17 months: range 1–72). There was no evidence of kidney damage in the last assessment in any of the 39 patients with kidney involvement. Conclusion In this group of patients, kidney involvement was more severe and common in the first weeks of the disease onset.
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