Native valve endocarditis caused by corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?
Cargando...
Fecha
2012
Título de la revista
Publicado en
Antimicrobial agents and chemotherapy, 1098-6596, Vol. 56, Nro. 6, 2012, p. 3461-3464
Publicado por
American Society for Microbiology
URL de la fuente
ISSN de la revista
Título del volumen
Resumen
Descripción
Abstract
We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.
Palabras clave
Keywords
Temáticas
Cefotaxima
Staphylococcus aureus resistente a la meticilina
Antibacterianos
Staphylococcus aureus resistente a la meticilina
Antibacterianos