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dc.contributor.authorBautista-Molano, Wilson
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorDe Avila, Juliette
dc.contributor.authorLondoño, John
dc.contributor.authorValle-Oñate, Rafael
dc.date.accessioned2020-07-27T20:55:37Z
dc.date.available2020-07-27T20:55:37Z
dc.identifier.issn0034-9887spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/3588
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.language.isoengspa
dc.publisherSociedad Médica de Santiagospa
dc.relation.ispartofseriesRevista médica de Chile, 0034-9887, Vol. 141, No. 9, 2013 p. 1182-1189spa
dc.relation.urihttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000900011spa
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleRemodelación ósea en espondiloartritisspa
dc.type.localArtículo de revista
dc.subject.keywordsAutoimmune diseasesspa
dc.subject.keywordsOsteogenesisspa
dc.subject.keywordsSpondylitisspa
dc.subject.keywordsAnkylosingspa
dc.identifier.doihttp://dx.doi.org/10.4067/S0034-98872013000900011spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalRevista médica de Chilespa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.identifier.instnameinstname:Universidad El Bosque
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.title.translatedBone remodeling in spondyloarthritisspa
dc.description.abstractenglishSpondyloarthritis is a group of several related but phenotypically distinct chronic inflammatory diseases, characterized by progressive new bone formation which leads to ankylosis and functional disability. Radiographic images evidence not only erosive changes but also overgrowth of bony structures called syndesmophytes. These inflammation, bone destruction and new bone formation are located in the entheses, which constitutes the primary organ of the disease. As a consequence, the inflammatory process results in excess of bone formation and the impact depends on the location, cell type, cytokines and local microenvironment factors. Several molecules playing a role as immune modulators or regulators of bone homeostasis, mediate the imbalance between bone resorption and formation. In the same way, animal models suggest that joint ankylosis may be independent from the effects of tumor necrosis factor alpha. Therefore, the process of new tissue (bone) formation can be considered as an additional therapeutic target. The Wnt signaling pathway, which is considered the primary regulator of osteoblastogenesis, constitutes a new research field of great interest in the last decade.spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abiertospa
dc.date.issued2013-09


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Except where otherwise noted, this item's license is described as Attribution 4.0 International