A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

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Munita_Jose_M._2014.pdf (349.97 KB)

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2013

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Antimicrobial Agents and Chemotherapy, 1098-6596, Vol. 57, No. 6, 2013 p. 2831-2833

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American Society for Microbiology

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https://hdl.handle.net/20.500.12495/3555

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https://aac.asm.org/content/57/6/2831.long

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Abstract

The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

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Enterococcus faecalis
Vancomicina
Daptomicina

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