A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis
Munita, Jose M.
Tran, Truc T.
Murray, Barbara E.
Arias, Cesar A.
Antimicrobial Agents and Chemotherapy, 1098-6596, Vol. 57, No. 6, 2013 p. 2831-2833
American Society for Microbiology
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The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
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