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dc.contributor.authorRossi, Flávia
dc.contributor.authorDiaz, Lorena
dc.contributor.authorWollam, Aye
dc.contributor.authorPanesso, Diana
dc.contributor.authorZhou, Yanjiao
dc.contributor.authorRincon, Sandra
dc.contributor.authorNarechania, Apurva
dc.contributor.authorXing, Galen
dc.contributor.authorDi Gioia, Thais S R
dc.contributor.authorDoi, André
dc.contributor.authorTran, Truc T
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorMunita, Jose M
dc.contributor.authorCarvajal, Lina P
dc.contributor.authorHernandez-Roldan, Alejandra
dc.contributor.authorBrandão, Denise
dc.contributor.authorvan der Heijden, Inneke Marie
dc.contributor.authorMurray, Barbara E
dc.contributor.authorPlanet, Paul J
dc.contributor.authorWeinstock, George M
dc.contributor.authorArias, Cesar A
dc.date.accessioned2020-07-17T17:14:53Z
dc.date.available2020-07-17T17:14:53Z
dc.identifier.issn1533-4406spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/3549
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherMassachusetts Medical Societyspa
dc.relation.ispartofseriesThe New England Journal of Medicine, 1533-4406, Vol. 370, 2014 p. 1524-1531spa
dc.relation.urihttps://www.nejm.org/doi/full/10.1056/nejmoa1303359spa
dc.titleTransferable Vancomycin resistance in a community-associated mrsa lineagetransferable vancomycin resistance in a community-associated MRSA lineagespa
dc.type.localArtículo de revista
dc.subject.decsSepsisspa
dc.subject.decsStaphylococcus aureusspa
dc.subject.decsMeticilinaspa
dc.identifier.doihttps://doi.org/10.1056/nejmoa1303359spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalThe New England Journal of Medicinespa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.identifier.instnameinstname:Universidad El Bosque
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.title.translatedTransferable vancomycin resistance in a community-associated MRSA lineagespa
dc.description.abstractenglishWe report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern.spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abiertospa
dc.date.issued2014-04-17


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