Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus causing infective endocarditis
Fecha
2017
Título de la revista
Publicado en
Antimicrobial agents and chemotherapy, 1098-6596, Vol. 61, Nro. 3, 2017
Publicado por
American Society for Microbiology
URL de la fuente
ISSN de la revista
Título del volumen
Resumen
Descripción
Abstract
We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.
Palabras clave
Keywords
Staphylococcus aureus, Ceftaroline, Endocarditis.
Temáticas
Farmacorresistencia bacteriana
Transmisión de enfermedad infecciosa
Insuficiencia del tratamiento
Transmisión de enfermedad infecciosa
Insuficiencia del tratamiento