Abdominal adiposity correlates with adenotonsillectomy outcome in obese adolescents with severe obstructive sleep apnea
Cargando...
Fecha
2012
Título de la revista
Publicado en
Pulmonary medicine, 2090-1844. Vol, 2012
Publicado por
Hindawi Pub
URL de la fuente
ISSN de la revista
Título del volumen
Resumen
Descripción
Abstract
Background. Obese adolescents with Obstructive Sleep Apnea (OSA) have a unique pathophysiology that combines adenotonsillar hypertrophy and increased visceral fat distribution. We hypothesized that in this population waist circumference (WC), as a clinical
marker of abdominal fat distribution, correlates with the likelihood of response to AT. Methods. We conducted a retrospective cohort study of obese adolescents (BMI ≥ 97th percentile) that underwent AT for therapy of severe OSA (n = 21). We contrasted WC and covariates in a group of subjects that had complete resolution of severe OSA after AT (n = 7) with those obtained in
subjects with residual OSA after AT (n = 14). Multivariate linear and logistic models were built to control possible confounders.
Results. WC correlated negatively with a positive AT response in young adolescents and the percentage of improvement in
obstructive apnea-hypopnea index (OAHI) after AT (P ≤ 0.01). Extended multivariate analysis demonstrated that the link between WC and AT response was independent of demographic variables, OSA severity, clinical upper airway assessment, obesity severity (BMI), and neck circumference (NC). Conclusion. The results suggest that in obese adolescents, abdominal fat distribution determined by WC may be a useful clinical predictor for residual OSA after AT.
Palabras clave
Keywords
Temáticas
Obesidad
Apnea obstructiva del sueño
Adolescente
Apnea obstructiva del sueño
Adolescente