Shape follows function: gastrointestinal signals for enterococcal colonization

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April H.Nguyen,William R.Miller,Cesar A.Arias_2019.pdf (434.42 KB)

Fecha

2019

Autores

Título de la revista

Publicado en

Trends in molecular medicine, 1471-499X, Vol. 25, Nro. 6, 2019, p. 464-466

Publicado por

Elsevier

URI

https://hdl.handle.net/20.500.12495/2561

URL de la fuente

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30100-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471491419301005%3Fshowall%3Dtrue

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Resumen

Descripción

Abstract

Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance

Palabras clave

Keywords

Antibiotic resistance, Daptomycin, Enterococcus

Temáticas

Tracto gastrointestinal
Farmacorresistencia microbiana
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