Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model

Miniatura

Archivos

Singh K.V., Arias C.A., Murray B.E._2019.pdf (204 KB)

Fecha

2019

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Título de la revista

Publicado en

Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 4, 2019, p. 1-4

Publicado por

American Society for Microbiology

URI

https://hdl.handle.net/20.500.12495/2327

URL de la fuente

https://aac.asm.org/content/63/4/e02627-18

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Descripción

Abstract

In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.

Palabras clave

Keywords

Tedizolid, Mouse peritonitis

Temáticas

Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas

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