Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 4, 2019, p. 1-4
American Society for Microbiology
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In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.
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