Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model

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Author
Singh, Kavindra V.
Arias, Cesar A 
Murray, Barbara 
Date
2019
Published in
Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 4, 2019, p. 1-4
Published for
American Society for Microbiology
URI
http://hdl.handle.net/20.500.12495/2327
Source's URL
https://aac.asm.org/content/63/4/e02627-18
DOI
https://doi.org/10.1128/AAC.02627-18
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Abstract
In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.
Keywords
Topics
Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
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