Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. Oralis

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Tran T.T., Mishra N.N., Seepersaud R., Diaz L., Rios R., Dinh A.Q., Garcia-de-la-Maria C., Rybak M.J., Miro J.M., Shelburne S.A., Sullam P.M., Bayer A.S., Arias C.A._2019.pdf (831.16 KB)

Fecha

2019

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Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 2, 2019, p. e01531-18

Publicado por

American society for microbiology

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https://hdl.handle.net/20.500.12495/2170

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https://aac.asm.org/content/63/2/e01531-18.abstract

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Abstract

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (Streptococcus mitis/S. oralis subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance in vitro. All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions

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Keywords

CdsA, PgsA, Daptomycin resistance

Temáticas

Streptococcus miti
Cardiolipinas
Daptomicina

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