Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome
Lynch, Rebecca M.
Montoya Cruz, Magelda
Bethony, Jeffrey Michael
Simon, Gary L.
Journal of infectious diseases, 1537-6613, Vol. 219, Nro. 1, 2019, p. 26-30
Oxford University Press
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The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
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