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dc.contributor.authorMena, Auxiliadora
dc.contributor.authorRuiz-Salas, Juan C.
dc.contributor.authorPuentes, Andrea
dc.contributor.authorDorado, Inmaculada
dc.contributor.authorRuiz-Veguilla, Miguel
dc.contributor.authorDe la Casa, Luis G.
dc.date.accessioned2020-01-23T21:41:42Z
dc.date.available2020-01-23T21:41:42Z
dc.identifier.issn1662-5153spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/1909
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.ispartofseriesFrontiers in Behavioral Neuroscience, 1662-5153, Vol. 10, 2016, p.1-9spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fnbeh.2016.00202spa
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleReduced prepulse inhibition as a biomarker of schizophreniaspa
dc.typearticlespa
dc.type.localartículospa
dc.subject.decsEsquizofreniaspa
dc.subject.decsTransmisión sinápticaspa
dc.subject.decsBiomarcadoresspa
dc.subject.keywordsEndophenotypespa
dc.subject.keywordsPrepulse inhibitionspa
dc.subject.keywordsStartlespa
dc.identifier.doihttps://doi.org/10.3389/fnbeh.2016.00202spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalFrontiers in Behavioral Neurosciencespa
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame: Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.cospa
dc.description.abstractenglishThe startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients at the acute stage as compared to a control group composed by 13 healthy participants, and that PPI but not startle habituation remained disrupted when registered 3 months after the discharge. These data point to the consideration of PPI, but not startle habituation, as a schizophrenia biomarker.spa
dc.rights.localAcceso abiertospa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf450spa
dc.date.issued2016


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International