Now showing items 1-10 of 21
Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in enterococcus faecalis
(National Academy of Sciences, 2019)
Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. Oralis
(American society for microbiology, 2019)
Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
(Oxford University Press, 2014)
High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated ...
Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus causing infective endocarditis
(American Society for Microbiology, 2017-03-01)
We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in ...
Transferable Vancomycin resistance in a community-associated mrsa lineagetransferable vancomycin resistance in a community-associated MRSA lineage
(Massachusetts Medical Society, 2014-04-17)
We report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired ...
Whole-genome analyses of enterococcus faecium isolates with diverse daptomycin MICs
(American Society for Microbiology, 2014-08)
Daptomycin (DAP) is a lipopeptide antibiotic frequently used as a "last-resort" antibiotic against vancomycin-resistant Enterococcus faecium (VRE). However, an important limitation for DAP therapy against VRE is the emergence ...
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis
(American Society for Microbiology, 2013-06)
The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a ...
Correlation between mutations in liaFSR of enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints
(American Society for Microbiology, 2012-06-04)
Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a ...