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Efficacy and safety of pembrolizumab plus docetaxel vs docetaxel alone in patients with previously treated advanced non-small cell lung cancer: the PROLUNG Phase 2 randomized clinical trial
(American Medical Association, 2020)
Importance: Because of socioeconomic factors, many patients with advanced non-small cell lung cancer (NSCLC) do not receive immunotherapy in the first-line setting. It is unknown if the combination of immunotherapy with ...
Squamous cell lung cancer: genomic evolution and personalized therapy
(Instituto Nacional de Salud Pública, 2019)
Objetivo. Revisar el estado del arte en relación con la información actual sobre el cáncer de pulmón de células escamosas (CPCE) y describir las anomalías genéticas reportadas, su efecto y los agentes terapéuticos más ...
EGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)
(Elsevier, 2018)
Objectives
Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting therapeutic options and impoverishing ...
Chronic and severe non-lichenoid oral ulcers induced by nivolumab-diagnostic and therapeutic challenge: a Case Report
(Karger, 2020)
Due to the widespread use of immune checkpoint inhibitors and the growing research efforts in this area, immune-mediated toxicity is well recognized. Nonetheless, few severe cases of oral or upper gastrointestinal tract ...
Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer
(Wiley-Blackwell, 2020)
Objective: CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer. However, the ...
Efficacy and safety of Levetiracetam vs. other antiepileptic drugs in Hispanic patients with glioblastoma
(Springer, 2018)
Epilepsy is a common symptom in patients with glioblastoma (GB). 213 patients with GB from RedLANO follow-up registry were included. All patients underwent surgery, if feasible, followed by chemoradiation based on temozolomide ...