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Genomic and molecular characterization of clinical isolates of Enterobacteriaceae harboring mcr-1 in Colombia, 2002 to 2016

Saavedra, Sandra Yamile; Diaz, Lorena; Wiesner, Magdalena; Arévalo, Stefany Alejandra; Correa, Adriana; Reyes, Jinnethe; Hidalgo, Andrea Melissa; De La Cadena, Elsa; Perenguez, Marcela Nataly; Montaño, Lucy Angeline; Ardila, Javier; Ríos, Rafael; Ovalle, María Victoria; Díaz, Paula; Porras, Paola; Villegas, Maria V.; Arias, Cesar A; Beltrán, mauricio; Duarte, Carolina (American Society for Microbiology, 2017)

Polymyxins are last-resort antimicrobial agents used to treat infections caused by carbapenem-resistant Enterobacteriaceae. Due to the worldwide dissemination of polymyxin resistance in animal and human isolates, we aimed ...

Daptomycin resistance in enterococci Is associated with distinct alterations of cell membrane phospholipid content

Mishra, Nagendra N.; Bayer, Arnold S.; Tran, Truc T.; Shamoo, Yousif; Mileykovskaya, Eugenia; Dowhan, William; Guan, Ziqiang; Arias, Cesar A (Public Library of Science, 2012)

Background The lipopeptide antibiotic, daptomycin (DAP) interacts with the bacterial cell membrane (CM). Development of DAP resistance during therapy in a clinical strain of Enterococcus faecalis was associated with mutations ...

Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris

Ayesha, Khan; Shropshire, William; Arias, Cesar A; Hanson, Blake; Wanger, Audrey; Dinh, An; Miller, William; Ostrosky-Zeichner, Luis (American Society for Microbiology, 2020)

Methicillin-susceptible, vancomycin-resistant staphylococcus aureus, Brazil

panesso, diana; Diaz, Lorena; Planet, Paul J.; Hugoneet, Jean-Emmanuel; Tran, Truc T.; Munita, Jose M.; Narechania, Apurva; Rincon, Sandra; Reyes, Jinnethe; Carvajal, Lina P.; Londoño, Alejandra; Smith, Hannah; Sebra, Robert; Deikus, Gintaras; Weinstock, George; Murray, Barbara; Rossi, Flavia; Arias, Cesar A; Arthur, Michel (Centers for Disease Control and Prevention, 2015)

We report characterization of a methicillin-susceptible, vancomycin-resistant bloodstream isolate of Staphylococcus aureus recovered from a patient in Brazil. Emergence of vancomycin resistance in methicillin-susceptible ...

Community-Associated MRSA Infection in Remote Amazon Basin Area, Peru

Garcia, Coralith; Reyes, Jinnethe; Astocondor, Lizeth; Arias, Cesar A; Carvajal, Lina P.; Seas, Carlos (Centers for Disease Control and Prevention, 2016)

Pharmacodynamic analysis of daptomycin-treated enterococcal bacteremia: It is time to change the breakpoint

Avery, Lindsay M; Kuti, Joseph L; Weisser, Maja; Egli, Adrian; Rybak, Michael J; Zasowski, Evan J; Arias, Cesar A (Oxford University Press, 2018)

Background Currently, there is debate over whether the daptomycin susceptibility breakpoint for enterococci (ie, minimum inhibitory concentration [MIC] ≤4 mg/L) is appropriate. In bacteremia, observational data support ...

Outcomes of patients with bloodstream infections caused by ampicillin-susceptible but penicillin-resistant Enterococcus faecalis: caution in interpreting the results

Cabrera, Nicolo; Malek, Alexandre E.; Aitken, Samuel; Arias, Cesar A (American Society for Microbiology, 2020)

Reply to cheng and chuang

Avery, Lindsay M; Kuti, Joseph L; Weisser, Maja; Egli, Adrian; Rybak, Michael J; Zasowski, Evan J; Arias, Cesar A; Contreras, German A; Chong, Pearlie P; Aitken, Samuel L; DiPippo, Adam J; Wang, Jann-Tay; Britt, Nicholas S; Nicolau, David P (Oxford University Press, 2019)

Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient

Alamarat, Zain I.; Babic, Jessica T.; Tran, Truc T.; Wootton, Susan H.; Dinh, An Q.; Miller, William R.; Hanson, Blake M.; Wanger, Audrey R.; Gary, Joshua L.; Arias, Cesar A; Pérez, Norma (American Society for Microbiology, 2019)

We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum ...

Disrupting membrane adaptation restores in vivo efficacy of antibiotics against multidrug-resistant enterococci and potentiates killing by human neutrophils

Rincon, Sandra; Panesso, Diana; Miller, William R; Singh, Kavindra V; Cruz, Melissa R; Khan, Ayesha; Dinh, An Q; Diaz, Lorena; Rios, Rafael; Shamoo, Yousif; Reyes, Jinnethe; Tran, Truc T; Garsin, Danielle A; Arias, Cesar A (Oxford University Press, 2019)

Daptomycin resistance in enterococci is often mediated by the LiaFSR system, which orchestrates the cell membrane stress response. Activation of LiaFSR through the response regulator LiaR generates major changes in cell ...