Now showing items 1-6 of 6
Investigation of temporal and spatial heterogeneities of the immune responses to Bordetella pertussis infection in the lung and spleen of mice via analysis and modeling of dynamic microarray gene expression data
(KeAi Communications, 2019)
Bordetella pertussis(B. pertussis) is the causative agent of pertussis, also referenced aswhooping cough. Although pertussis has been appropriately controlled by routine im-munization of infants, it has experienced a ...
Genomic and epidemiological evidence of a dominant panton-valentine leucocidin-positive methicillin resistant staphylococcus aureus lineage in Sri Lanka and presence among isolates from the United Kingdom and Australia
(Frontiers Media, 2019-04-26)
Objective: To undertake the first detailed genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) isolated in Sri Lanka. Methods: A prospective observational study was performed on 94 MRSA isolates ...
Range expansion and the origin of USA300 North American Epidemic Methicillin-Resistant Staphylococcus aureus
(American Society for Microbiology, 2018-01-02)
The USA300 North American epidemic (USA300-NAE) clone of methicillinresistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but ...
Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface
(Public Library of Science, 2018-12-05)
Inactivating mutations in the control of virulence two-component regulatory system (covRS) often account for the hypervirulent phenotype in severe, invasive group A streptococcal (GAS) infections. As CovR represses production ...
Daptomycin-resistant enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids
(American Society for Microbiology, 2013-07-23)
Treatment of multidrug-resistant enterococci has become a challenging clinical problem in hospitals around the world due to the lack of reliable therapeutic options. Daptomycin (DAP), a cell membrane-targeting cationic ...
Phylogenomic classification and the evolution of clonal complex 5 Methicillin-Resistant Staphylococcus aureus in the Western Hemisphere
Clonal complex 5 methicillin-resistant Staphylococcus aureus (CC5-MRSA) includes multiple prevalent clones that cause hospital-associated infections in the Western Hemisphere. Here, we present a phylogenomic study of these ...