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dc.contributor.authorFernandez-Cuesta, Lynnette
dc.contributor.authorAvogbe, Patrice Hodonou
dc.contributor.authorLeblay, Noemie
dc.contributor.authorDelhomme, Tiffany M.
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorAbedi-Ardekani, Behnoush
dc.contributor.authorChanudet, Estelle
dc.contributor.authorOlivier, Magali
dc.contributor.authorZaridze, David
dc.contributor.authorMukeria, Anush
dc.contributor.authorVilensky, Marta
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorPolesel, Jerry
dc.contributor.authorSimonato, Lorenzo
dc.contributor.authorCanova, Cristina
dc.contributor.authorLagiou, Pagona
dc.contributor.authorBrambilla, Christian
dc.contributor.authorByrnes, Graham
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorLe Calvez-Kelm, Florence
dc.contributor.authorMcKay, James D.
dc.contributor.authorBrennan, Paul
dc.contributor.authorBrambilla, Elisabeth
dc.contributor.authorPerdomo, Sandra
dc.date.accessioned2019-08-14T17:08:51Z
dc.date.available2019-08-14T17:08:51Z
dc.identifier.issn2352-3964spa
dc.identifier.urihttp://hdl.handle.net/20.500.12495/1611
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.ispartofseriesEBioMedicine, 2352-3964, Vol. 10, August, 2016, p.117-123spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2352396416302894?via%3Dihubspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSmall-Cell lung cancerspa
dc.subjectTP53 mutationsspa
dc.subjectEarly detectionspa
dc.subjectScreeningspa
dc.titleIdentification of circulating tumor DNA for the early detection of small-cell lung cancerspa
dc.typearticlespa
dc.type.localartículospa
dc.subject.decsÁcidos nucleicos libres de célulasspa
dc.subject.decsADN tumoral circulantespa
dc.subject.decsCarcinoma pulmonar de células pequeñasspa
dc.subject.decsGenes supresores de tumorspa
dc.subject.decsDiagnóstico precozspa
dc.identifier.doihttps://doi.org/10.1016/j.ebiom.2016.06.032spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.publisher.journalEBioMedicinespa
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame: Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.cospa
dc.description.abstractenglishCirculating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play a crucial role in the detection of pre-clinical cancer. Small-cell lung cancer (SCLC) is an excellent candidate for early detection given there are no successful therapeutic options for late-stage disease, and it displays almost universal inactivation of TP53. We assessed the presence of TP53 mutations in the cell-free DNA (cfDNA) extracted from the plasma of 51 SCLC cases and 123 non-cancer controls. We identified mutations using a pipeline specifically designed to accurately detect variants at very low fractions. We detected TP53 mutations in the cfDNA of 49% SCLC patients and 11.4% of non-cancer controls. When stratifying the 51 initial SCLC cases by stage, TP53 mutations were detected in the cfDNA of 35.7% early-stage and 54.1% late-stage SCLC patients. The results in the controls were further replicated in 10.8% of an independent series of 102 non-cancer controls. The detection of TP53 mutations in 11% of the 225 non-cancer controls suggests that somatic mutations in cfDNA among individuals without any cancer diagnosis is a common occurrence, and poses serious challenges for the development of ctDNA screening tests.spa
dc.rights.localAcceso abiertospa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf428spa
dc.date.issued2016


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International